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. 2025 Jun 5;14(6):579.
doi: 10.3390/antibiotics14060579.

Candidozyma auris Outbreak and Its Effective Control in a General Hospital

Flora V Kontopidou  1 , Maria Antonopoulou  1 , Anastasia Votsi  2 , Vassiliki Papoutsaki  2 , Vassiliki Bereri  3 , Evangelia Kourkoulou  3 , Amalia Rompola  4 , Georgia Tsokou  4 , Anna Pavli  3 , Olga Maria Koutantelia  1 , Maria Siopi  5 , Sevasti Leventaki  5 , Joseph Meletiadis  5 , George L Daikos  1
Affiliations

Candidozyma auris Outbreak and Its Effective Control in a General Hospital

Flora V Kontopidou et al. Antibiotics (Basel). .

Abstract

Background/Objectives:Candidozyma auris (C. auris) is a multidrug-resistant pathogen recognized as a serious global public health threat. Herein, we report a C. auris outbreak that was successfully contained in a general hospital located in Athens, Greece. Methods: This study was conducted between December 2021 and December 2023. Upon identification of the first imported case of C. auris, the following infection control measures were applied in a stepwise approach: the promotion of hand hygiene, contact precautions and isolation, chlorhexidine gluconate bathing of patients, enhanced environmental cleaning, and active surveillance cultures of all high-risk patients upon admission. Active surveillance cultures were performed weekly in non-colonized ICU patients. Results: A total of 1564 screening samples from 890 patients were analyzed. Sixty-three patients were identified to be colonized and three to be infected with C. auris. After implementing screening and enhanced environmental cleaning, the quarterly incidence of hospital-acquired cases decreased from 0.37 to 0.04 cases per 1000 patient-days (slope of linear trend: -0.08; 95% CI: -0.16 to -0.0004; p = 0.05), despite the continuous inflow of already colonized patients. Conclusions: A bundle of infection control measures, including active surveillance cultures upon admission and enhanced environmental cleaning, can contain C. auris dissemination in acute healthcare settings.

Keywords: C. auris; active surveillance; healthcare-associated infections; infection prevention and control.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Number of patients with C. auris per quarter. Each quarter depicts all hospitalized patients with C. auris (new cases (imported or hospital-acquired), unknown cases, and old cases consisting of those who remained in the hospital for a period longer than the quarter in which they were first detected). The letters a, b, c, and d indicate the respective quarter of the year.
Figure 2
Figure 2
Quarterly incidence rate of new C. auris cases during post-intervention period. Columns indicate imported cases, whereas line indicates hospital-acquired cases. The letters a, b, c, and d indicate the respective quarter of the year.
Figure 3
Figure 3
Intervention measures according to time periods.
See this image and copyright information in PMC

References

    1. Sears D., Schwartz B.S. Candida auris: An Emerging Multidrug-Resistant Pathogen. Int. J. Infect. Dis. 2017;63:95–98. doi: 10.1016/j.ijid.2017.08.017. - DOI - PubMed
    1. Meis J.F., Chowdhary A. Candida auris: A Global Fungal Public Health Threat. Lancet Infect. Dis. 2018;18:1298–1299. doi: 10.1016/S1473-3099(18)30609-1. - DOI - PubMed
    1. Lyman M., Forsberg K., Sexton D.J., Chow N.A., Lockhart S.R., Jackson B.R., Chiller T. Worsening Spread of Candida auris in the United States, 2019 to 2021. Ann. Intern. Med. 2023;176:489–495. doi: 10.7326/M22-3469. - DOI - PMC - PubMed
    1. Lionakis M.S., Chowdhary A. Candida auris Infections. New Engl. J. Med. 2024;391:1924–1935. doi: 10.1056/NEJMra2402635. - DOI - PubMed
    1. Suphavilai C., Ko K.K.K., Lim K.M., Tan M.G., Boonsimma P., Chu J.J.K., Goh S.S., Rajandran P., Lee L.C., Tan K.Y., et al. Detection and Characterisation of a Sixth Candida auris Clade in Singapore: A Genomic and Phenotypic Study. Lancet Microbe. 2024;5:100878. doi: 10.1016/S2666-5247(24)00101-0. - DOI - PubMed

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