Preventing Delirium in Hospitalized Patients: No Magic Bullets

Jessica D Spence^{1

2}, Renée Fournier³, Emilie Belley-Côté^{2

4}

Affiliations

¹ Departments of Anesthesia, Critical Care, and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton, ON, Canada.
² Perioperative Research Division, Population Health Research Institute, World Health Research Trust, Hamilton, ON, Canada.
³ Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
⁴ Departments of Medicine (Cardiology), Critical Care, and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton, ON, Canada.

PMID: 40558607
DOI: 10.1097/CCM.0000000000006755

Preventing Delirium in Hospitalized Patients: No Magic Bullets

Jessica D Spence et al. Crit Care Med. 2025.

. 2025 Sep 1;53(9):e1827-e1829.

doi: 10.1097/CCM.0000000000006755. Epub 2025 Jun 25.

Authors

Jessica D Spence^{1

2}, Renée Fournier³, Emilie Belley-Côté^{2

4}

Affiliations

¹ Departments of Anesthesia, Critical Care, and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton, ON, Canada.
² Perioperative Research Division, Population Health Research Institute, World Health Research Trust, Hamilton, ON, Canada.
³ Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
⁴ Departments of Medicine (Cardiology), Critical Care, and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton, ON, Canada.

PMID: 40558607
DOI: 10.1097/CCM.0000000000006755

No abstract available

Keywords: delirium; orexin receptor antagonists; research methods.

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Conflict of interest statement

Dr. Spence’s institution received funding from AOP Pharma; she received funding from VarmX and Trimedic; and she received support for article research from the Heart and Stroke Foundation of Canada New Investigator Award. Dr. Belley-Côté’s institution received funding from Abbott Laboratories and Trimedic Therapeutics; she received funding from Bayer, BMS-Pfizer, and Roche Diagnostics; and she is supported by the Clive Kearon career award (McMaster University, Department of Medicine). Ms. Fournier has disclosed that she does not have any potential conflicts of interest.

References

1. Toor B, Ray LB, Pozzobon A, et al.: Sleep, orexin and cognition. Front Neurol Neurosci 2021; 45:38–51
1. Ángeles-Castellanos M, Ramírez-Gonzalez F, Ubaldo-Reyes L, et al.: Loss of melatonin daily rhythmicity is asociated with delirium development in hospitalized older adults. Sleep Sci 2016; 9:285–288
1. de Oliveira HM, Gallo Ruelas M, Valeriano FV, et al.: Efficacy of ramelteon, suvorexant, and lemborexant for delirium prevention in hospitalized patients: A systematic review and meta-analysis. Crit Care Med 2025; 53:e1781–e1789
1. Sharma R, Sahota P, Thakkar MM: Melatonin promotes sleep in mice by inhibiting orexin neurons in the perifornical lateral hypothalamus. J Pineal Res 2018; 65:e12498
1. Lewis K, Balas MC, Stollings JL, et al.: A focused update to the clinical practice guidelines for the prevention and management of pain, anxiety, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med 2025; 53:e711–e727

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Preventing Delirium in Hospitalized Patients: No Magic Bullets

Affiliations

Preventing Delirium in Hospitalized Patients: No Magic Bullets

Authors

Affiliations

Conflict of interest statement

References

LinkOut - more resources

Full Text Sources