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Review
. 2025 Jun 5;6(2):52.
doi: 10.3390/neurosci6020052.

Natural Compounds That Target Glioma Stem Cells

Mariia Yaroshenko  1 , Monika Christoff  1 , Mateusz Ścibiorski  2 , Karolina Surowiec  1 , Joanna Jakubowicz-Gil  2 , Joanna Sumorek-Wiadro  2
Affiliations
Review

Natural Compounds That Target Glioma Stem Cells

Mariia Yaroshenko et al. NeuroSci. .

Abstract

Gliomas are the most common central nervous system tumors and account for 30% of all primary brain tumors, 80% of all malignant ones, and the vast majority of deaths that are caused by brain tumors. Among them, glioblastoma multiforme has the most aggressive and invasive course. Due to its heterogeneity, it is difficult to treat, and one of the reasons for this are glioma stem cells (GSCs). Therapies such as radiotherapy and chemotherapy are used to treat gliomas but do not bring the expected results. Therefore, treatments targeting glioma stem cells are emerging. A promising strategy is to target GSCs with natural compounds. This review aims to describe the problem of glioma stem cells, the treatment of gliomas, and therapies based on natural compounds, which are promising for the future.

Keywords: glioblastoma; glioma stem cells; glioma treatment; natural compounds.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Differences between proneuronal (blue) and mesenchymal (green) glioma stem cells (GSCs).
Figure 2
Figure 2
Mechanism of anticancer activity of naturally derived compounds against GSCs.
See this image and copyright information in PMC

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References

    1. Molinaro A.M., Taylor J.W., Wiencke J.K., Wrensch M.R. Genetic and molecular epidemiology of adult diffuse glioma. Nat. Rev. Neurol. 2019;15:405–417. doi: 10.1038/s41582-019-0220-2. - DOI - PMC - PubMed
    1. Schaff L.R., Mellinghoff I.K. Glioblastoma and Other Primary Brain Malignancies in Adults: A Review. JAMA. 2023;329:574–587. doi: 10.1001/jama.2023.0023. - DOI - PMC - PubMed
    1. D’Alessio A., Proietti G., Sica G., Scicchitano B.M. Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue. Cancers. 2019;11:469. doi: 10.3390/cancers11040469. - DOI - PMC - PubMed
    1. Angom R.S., Nakka N.M.R., Bhattacharya S. Advances in Glioblastoma Therapy: An Update on Current Approaches. Brain Sci. 2023;13:1536. doi: 10.3390/brainsci13111536. - DOI - PMC - PubMed
    1. Wu W., Klockow J.L., Zhang M., Lafortune F., Chang E., Jin L., Wu Y., Daldrup-Link H.E. Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance. Pharmacol. Res. 2021;171:105780. doi: 10.1016/j.phrs.2021.105780. - DOI - PMC - PubMed

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