Generalized pustular psoriasis in a patient with asthma following dupilumab and tezepelumab therapy

Misaki Kawakami¹, Hana Takeshita¹, Atsushi Oda¹, Takeshi Namiki^{1

2}, Keiko Komatsuzaki³, Yasunari Miyazaki³, Naoko Okiyama^{1

2}

Affiliations

¹ Department of Dermatology, Institute of Science Tokyo (IST) Hospital, Tokyo, Japan.
² Department of Dermatology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo (IST), Tokyo, Japan.
³ Department of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo (IST), Tokyo, Japan.

Case Reports

Misaki Kawakami et al. J Dtsch Dermatol Ges. 2025 Nov.

. 2025 Nov;23(11):1458-1460.

doi: 10.1111/ddg.15800. Epub 2025 Jun 25.

Misaki Kawakami¹, Hana Takeshita¹, Atsushi Oda¹, Takeshi Namiki^{1

2}, Keiko Komatsuzaki³, Yasunari Miyazaki³, Naoko Okiyama^{1

2}

¹ Department of Dermatology, Institute of Science Tokyo (IST) Hospital, Tokyo, Japan.
² Department of Dermatology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo (IST), Tokyo, Japan.
³ Department of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo (IST), Tokyo, Japan.

No abstract available

Keywords: asthma; generalized pustular psoriasis; interleukin‐13; interleukin‐36; interleukin‐4; thymic stromal lymphopoietin.

References

1. Brumfiel CM, Patel MH, Zirwas MJ. Development of psoriasis during treatment with dupilumab: a systematic review. J Am Acad Dermatol. 2022;86(3):708‐709.
1. Jaulent L, Staumont‐Sallé D, Tauber M, et al. De novo psoriasis in atopic dermatitis patients treated with dupilumab: a retrospective cohort. J Eur Acad Dermatol Venereol. 2021;35(4):e296‐e297.
1. Choon SE, Foley PA, Asawanonda P, et al. Asia‐Pacific consensus recommendations on the management of Generalized pustular psoriasis. J Dermatol. 2024;51(12):1579‐1595.
1. Puig L, Choon SE, Gottlieb AB, et al. Generalized pustular psoriasis: A global Delphi consensus on clinical course, diagnosis, treatment goals and disease management. J Eur Acad Dermatol Venereol. 2023;37(4):737‐752.
1. Guenova E, Skabytska Y, Hoetzenecker W, et al. IL‐4 abrogates T(H)17 cell‐mediated inflammation by selective silencing of IL‐23 in antigen‐presenting cells. Proc Natl Acad Sci U S A. 2015;112(7):2163‐2168.