Bridging the Gap: The Neuro-immune Axis as a Key Player in Neurodegenerative Disorders
- PMID: 40560460
- DOI: 10.1007/s12264-025-01439-8
Bridging the Gap: The Neuro-immune Axis as a Key Player in Neurodegenerative Disorders
Abstract
Neurodegenerative diseases encompass a diverse array of disorders that have a profoundly detrimental impact on human health, characterized by their intricate and multifaceted pathogenesis. In the recent past, a growing body of scientific research has begun to shed light on the critical involvement of the neuro-immune axis in the onset and advancement of these debilitating conditions. This comprehensive review article delves into the intricate composition of the neuro-immune axis, elucidating the complex mechanisms through which it exerts its influence in the context of neurodegenerative diseases. Furthermore, it explores the potential therapeutic applications of targeting the neuro-immune axis for the management and treatment of these diseases. This extensive examination aims to offer new perspectives and innovative strategies that could pave the way for more effective treatments for neurodegenerative diseases, thereby providing hope for those afflicted by these challenging conditions.
Keywords: Immune cells; Immune system; Nervous system; Neurodegenerative diseases.
© 2025. Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences.
Conflict of interest statement
Conflict of interest: The authors declare that there are no conflicts of interest.
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References
-
- Hodo TW, de Aquino MTP, Shimamoto A, Shanker A. Critical neurotransmitters in the neuroimmune network. Front Immunol 1869, 2020: 11.
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