Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jun 25.
doi: 10.1007/s12264-025-01439-8. Online ahead of print.

Bridging the Gap: The Neuro-immune Axis as a Key Player in Neurodegenerative Disorders

Affiliations
Review

Bridging the Gap: The Neuro-immune Axis as a Key Player in Neurodegenerative Disorders

Tingting Liu et al. Neurosci Bull. .

Abstract

Neurodegenerative diseases encompass a diverse array of disorders that have a profoundly detrimental impact on human health, characterized by their intricate and multifaceted pathogenesis. In the recent past, a growing body of scientific research has begun to shed light on the critical involvement of the neuro-immune axis in the onset and advancement of these debilitating conditions. This comprehensive review article delves into the intricate composition of the neuro-immune axis, elucidating the complex mechanisms through which it exerts its influence in the context of neurodegenerative diseases. Furthermore, it explores the potential therapeutic applications of targeting the neuro-immune axis for the management and treatment of these diseases. This extensive examination aims to offer new perspectives and innovative strategies that could pave the way for more effective treatments for neurodegenerative diseases, thereby providing hope for those afflicted by these challenging conditions.

Keywords: Immune cells; Immune system; Nervous system; Neurodegenerative diseases.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: The authors declare that there are no conflicts of interest.

Similar articles

References

    1. Li Z, Zhang Y, Ji M, Wu C, Zhang Y, Ji S. Targeting ferroptosis in neuroimmune and neurodegenerative disorders for the development of novel therapeutics. Biomed Pharmacother 2024, 176: 116777. - PubMed - DOI
    1. González H, Elgueta D, Montoya A, Pacheco R. Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases. J Neuroimmunol 2014, 274: 1–13. - PubMed - DOI
    1. Ringheim GE, Conant K. Neurodegenerative disease and the neuroimmune axis (Alzheimer’s and Parkinson’s disease, and viral infections). J Neuroimmunol 2004, 147: 43–49. - PubMed - DOI
    1. Hodo TW, de Aquino MTP, Shimamoto A, Shanker A. Critical neurotransmitters in the neuroimmune network. Front Immunol 1869, 2020: 11.
    1. Borst K, Dumas AA, Prinz M. Microglia: Immune and non-immune functions. Immunity 2021, 54: 2194–2208. - PubMed - DOI

LinkOut - more resources