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. 2025 Jun 25:ehaf369.
doi: 10.1093/eurheartj/ehaf369. Online ahead of print.

Atrial fibrillation in former world-class rowers: role of environmental and genetic factors

M Darragh Flannery  1   2   3 , Rodrigo Canovas  4   5 , Kristel Janssens  1   2   6 , Amy M Mitchell  1   2 , Paolo D'Ambrosio  1   2   3 , Luke W Spencer  1   2   3 , Stephanie J Rowe  1   2   3   7 , Elizabeth D Paratz  1   3   7   8 , Guido Claessen  9   10 , Marius Myrstad  11 , Sergio Ruiz-Carmona  4   12 , Paul E Young  8 , Monique Ohanian  8 , Magdalena Soka  8 , Emma M Rath  8 , Eleni Giannoulatou  8 , Renee Johnson  8   13 , Chenglong Yu  14 , Paul Lacaze  14 , Adrian D Elliott  15 , Prashanthan Sanders  15 , Rik Willems  16 , Hein Heidbuchel  17   18 , Jonathan M Kalman  3   19 , Diane Fatkin  8   13   20 , Andre La Gerche  1   2   3   7   8
Affiliations

Atrial fibrillation in former world-class rowers: role of environmental and genetic factors

M Darragh Flannery et al. Eur Heart J. .

Abstract

Background and aims: Endurance sport has been associated with an increased risk of atrial fibrillation (AF). The aim of this study was to assess the extent to which this is due to exercise burden or genetic predisposition.

Methods: Former rowers aged 45-80 years who competed at international championships were compared with a control group extracted from the UK Biobank, matched (1:100) for age and sex. Evaluation included 12-lead and Holter electrocardiograms, cardiac magnetic resonance imaging, and genetic analyses including rare variant evaluation and derivation of a validated AF polygenic risk score (AF-PRS).

Results: Of 121 rowers [age 62 years (interquartile range 54-69), 74% male], 26 (21.5%) had AF as compared with 364 of 11 495 control subjects (3.2%), prevalence risk ratio 6.8 [95% confidence interval (CI) 4.7-9.8]. Incident AF over 4-year follow-up was also greater [6 of 95 rowers (6.3%) vs 252 of 11 131 controls (2.3%), hazard ratio 2.8 (95% CI 1.6-5.0)]. Compared with controls, athletes demonstrated greater structural and electrophysiological cardiac remodelling. Athletes had similar cardiovascular risk factor profiles but a higher stroke prevalence than controls [3.3% vs 1.1%, risk ratio 3.0 (95% CI 1.1-7.9)]. Rare pathogenic and likely pathogenic variants in cardiomyopathy genes had low prevalence in athletes (2.7%) and were not enriched in those with AF. In contrast, in those subjects with a high AF-PRS (defined by the upper quartile in a healthy reference population) the odds of having AF increased 3.7-fold in athletes (95% CI 1.5-9.4) and 2.0-fold in controls (95% CI 1.7-2.4; P = .37 for between-group comparisons).

Conclusions: Despite having a favourable cardiovascular risk factor profile compared with controls, elite endurance athletes had a markedly higher prevalence and incidence of AF. These data suggest that exercise-induced cardiac remodelling and genetic susceptibility contribute to AF in endurance athletes.

Keywords: Arrhythmia; Athlete; Atrial fibrillation; Genomics; Polygenic.

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