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Review
. 2025;34(6):505-508.
doi: 10.1159/000547047. Epub 2025 Jun 25.

Red Blood Cells and Their Immunoregulatory Role

Angela Risso  1 , Guglielmo Antonutto  2
Affiliations
Review

Red Blood Cells and Their Immunoregulatory Role

Angela Risso et al. Med Princ Pract. 2025.

Abstract

<p>The physiological roles played by red blood cells (RBCs), i.e., oxygen transport to all cells and tissues, CO2 delivery to the lungs, control of pH in blood, and ions transport into and out of the cell membrane, have been investigated extensively over the past decades. The roles mature and immature RBCs play, while in the blood vessels, when they come in contact with other blood and endothelial cells, are only partially known. Here we will focus on the ability of RBC to modulate innate and adaptive immune responses when they interact with cells or molecules encountered during their flow in the vessels. We will outline the possible clinical impact on treatment of some diseases, such as autoimmune diseases, inflammatory pathologies, or tumors, where immunotherapy can be applied. </p>.

Keywords: Dendritic cells; Innate and adaptive immunity; Red blood cells.

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Conflict of interest statement

The authors have no conflict of interest to declare.

References

    1. Niu C, Zhang J. Immunoregulation role of the erythroid cells. Front Immunol. 2024;15:1466669. - PMC - PubMed
    1. de Back DZ, Kostova EB, van Kraaij M, van denBerg TK, van Bruggen R. Of macrophages and red blood cells; a complex love story. Front Physiol. 2014;5:9. - PMC - PubMed
    1. Pretini V, Koenen MH, Kaestner L, Fens MHAM, Schiffelers RM, Bartels M, et al. Red blood cells: chasing interactions. Front Physiol. 2019;10:945. - PMC - PubMed
    1. Alshalani A, Beuger BM, vanBruggen R, Acker JP, Juffermans NP. Cultured CD71+erythroid cells modulate the host immune response. Transfus Med. 2023;33(3):257–62. - PubMed
    1. Oldenborg PA, Zheleznyak A, Fang YF, Lagenaur CF, Gresham HD, Lindberg FP. Role of CD47 as a marker of self on red blood cells. Science. 2000;288(5473):2051–4. - PubMed

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