Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jun 25;34(176):240175.
doi: 10.1183/16000617.0175-2024. Print 2025 May.

The impact of smoking on lung cancer patients

Affiliations
Review

The impact of smoking on lung cancer patients

Fabrizio Minervini et al. Eur Respir Rev. .

Abstract

Although smoking prevalence has shown a decreasing trend, the total number of smokers remains high due to population growth. Smoking causes several diseases, including lung cancer, COPD, coronary heart disease, stroke and peripheral vascular disease. Most of the adverse effects of smoking are reversible and smoking cessation treatments are a cost-effective and high-impact intervention for reducing the risk of mortality and morbidity from smoking-related illness. Smoking cessation may have a significant impact in patients diagnosed with lung cancer, as continued tobacco use can critically compromise treatment efficacy, increase the risk of recurrence and reduce overall survival. Moreover, the benefits of smoking cessation in lung cancer patients can also improve quality of life. The tremendous health and economic consequences of the smoking epidemic should make tobacco control a top priority for governments worldwide. This review aims to highlight the necessity of incorporating smoking cessation as a standard component of lung cancer treatment protocols to enhance patients' clinical outcomes and quality of life. At the same time, we identified a lack of current evidence regarding the optimal timing of smoking cessation among lung cancer patients, which provides the basis for further investigation.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: All authors have nothing to disclose.

References

    1. Wynder EL, Graham EA. Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma; a study of 684 proved cases. J Am Med Assoc 1950; 143: 329–336. doi: 10.1001/jama.1950.02910390001001 - DOI - PubMed
    1. Doll R, Hill AB. Smoking and carcinoma of the lung; preliminary report. Br Med J 1950; 2: 739–748. doi: 10.1136/bmj.2.4682.739 - DOI - PMC - PubMed
    1. Wynder EL, Stellman SD. Comparative epidemiology of tobacco-related cancers. Cancer Res 1977; 37: 4608–4622. - PubMed
    1. Sasco AJ, Secretan MB, Straif K. Tobacco smoking and cancer: a brief review of recent epidemiological evidence. Lung Cancer 2004; 45: Suppl. 2, S3–S9. doi: 10.1016/j.lungcan.2004.07.998 - DOI - PubMed
    1. Wynder EL, Hoffmann D. Tobacco and tobacco smoke. Semin Oncol 1976; 3: 5–15. - PubMed