Do Anti-PCSK9 Monoclonal Antibodies Have Pleiotropic Effects?
- PMID: 40562485
- PMCID: PMC12230480
- DOI: 10.1016/j.jacbts.2025.04.005
Do Anti-PCSK9 Monoclonal Antibodies Have Pleiotropic Effects?
Keywords: (18)F-FDG-PET imaging; PCSK9 inhibition; acute myocardial infarction; myocardial inflammation.
Conflict of interest statement
Funding Support and Author Disclosures Dr Ferri has received honoraria from Pfizer, Amgen, Daiichi Sankyo, Bristol Myers Squibb, Relmada Therapeutics, and Pharmanutra.
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References
-
- Byrne R.A., Rossello X., Coughlan J.J., et al. 2023 ESC guidelines for the management of acute coronary syndromes. Eur Heart J. 2023;44:3720–3826. - PubMed
-
- Ziogos E., Harb T., Valenta I., et al. Impact of in-hospital PCSK9 inhibition on myocardial inflammation after myocardial infarction: a randomized clinical trial. JACC Basic Transl Sci. 2025;10(6):709–720. - PubMed
-
- Gargiulo P., Basile C., Galasso G., et al. Strike early-strike strong lipid-lowering strategy with proprotein convertase subtilisin/kexin type 9 inhibitors in acute coronary syndrome patients: real-world evidence from the AT-TARGET-IT registry. Eur J Prev Cardiol. 2024;31:1806–1816. - PubMed
-
- Nissen S.E., Tuzcu E.M., Schoenhagen P., et al. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med. 2005;352:29–38. - PubMed
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