Calopy - an advanced framework for the integration and analysis of indirect calorimetry data

Stefan Loipfinger^{1

2}, Matthias Grosholz, Santhosh Kumar², Helin Erbilir², Kenneth Allen Dyar^{3

4}, Timo Dirk Müller^{4

5

6}, Stephan Grein^{7

8}, Jan Rozman⁹, Martin Klingenspor^{10

11}, Carola Meyer¹², Dominik Lutter^{13

14}

Affiliations

¹ Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
² Computational Discovery Research Group, Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany.
³ Metabolic Physiology, Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Munich, Neuherberg, Germany.
⁴ German Center for Diabetes Research (DZD), Neuherberg, Germany.
⁵ Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.
⁶ Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University, Munich, Germany.
⁷ Life and Medical Sciences (LIMES) Institute, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
⁸ Bonn Center for Mathematical Life Sciences, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
⁹ Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.
¹⁰ Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Research Department of Molecular Life Sciences, Technical University of Munich, Freising, Germany.
¹¹ Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany.
¹² Institute of Pharmacology, University of Marburg, Marburg, Germany.
¹³ Computational Discovery Research Group, Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany. dominik.lutter@helmholtz-munich.de.
¹⁴ German Center for Diabetes Research (DZD), Neuherberg, Germany. dominik.lutter@helmholtz-munich.de.

PMID: 40562969
DOI: 10.1038/s42255-025-01316-8

Calopy - an advanced framework for the integration and analysis of indirect calorimetry data

Stefan Loipfinger et al. Nat Metab. 2025 Jun.

. 2025 Jun;7(6):1093-1095.

doi: 10.1038/s42255-025-01316-8.

Authors

Affiliations

¹ Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
² Computational Discovery Research Group, Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany.
³ Metabolic Physiology, Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Munich, Neuherberg, Germany.
⁴ German Center for Diabetes Research (DZD), Neuherberg, Germany.
⁵ Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.
⁶ Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University, Munich, Germany.
⁷ Life and Medical Sciences (LIMES) Institute, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
⁸ Bonn Center for Mathematical Life Sciences, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
⁹ Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.
¹⁰ Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Research Department of Molecular Life Sciences, Technical University of Munich, Freising, Germany.
¹¹ Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany.
¹² Institute of Pharmacology, University of Marburg, Marburg, Germany.
¹³ Computational Discovery Research Group, Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany. dominik.lutter@helmholtz-munich.de.
¹⁴ German Center for Diabetes Research (DZD), Neuherberg, Germany. dominik.lutter@helmholtz-munich.de.

PMID: 40562969
DOI: 10.1038/s42255-025-01316-8

No abstract available

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Conflict of interest statement

Competing interests: T.D.M. holds stocks from Eli Lilly and receives research funding from Novo Nordisk. T.D.M. further received speaking fees within the past 3 years from Merck, AstraZeneca, Boehringer Ingelheim, Eli Lilly and Novo Nordisk. All remaining authors declare no competing interests.

References

1. Ferrannini, E. Metabolism 37, 287–301 (1988). - DOI - PubMed
1. Weir, J. B. & de, V. J. Physiol. 109, 1–9 (1949). - DOI - PubMed - PMC
1. Loffler, M. C. et al. Mol. Metab. 51, 101237 (2021). - DOI - PubMed - PMC
1. Tschop, M. H. et al. Nat. Methods 9, 57–63 (2011). - DOI - PubMed - PMC
1. Mina, A. I. et al. Cell Metab. 28, 656–666.e651 (2018). - DOI - PubMed - PMC

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Calopy - an advanced framework for the integration and analysis of indirect calorimetry data

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Calopy - an advanced framework for the integration and analysis of indirect calorimetry data

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