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Review
. 2025 Jun 13;12(6):652.
doi: 10.3390/bioengineering12060652.

The Risks Associated with Inhalation Exposure to Cosmetics and Potential for Assessment Using Lung Organoids

Yiguang Li  1 , Xin Luo  2   3 , Rong Hu  4 , Lifeng Tang  5 , Qi Xiang  1   2   3
Affiliations
Review

The Risks Associated with Inhalation Exposure to Cosmetics and Potential for Assessment Using Lung Organoids

Yiguang Li et al. Bioengineering (Basel). .

Abstract

This review addresses the exposure risks associated with the inhalation of aerosolized cosmetic products and explores the utility of lung organoids in assessing these risks. Aerosolized cosmetics such as sprays pose potential health hazards through inhalation, necessitating a thorough evaluation of exposure levels. Traditional methods for assessing inhalation risks have limitations, prompting the exploration of more sophisticated models. Lung organoids, three-dimensional structures derived from stem cells, offer a biologically relevant model for studying lung responses to inhaled substances. This review discusses the construction of lung organoids, their characteristics, and the advantages that they provide over conventional models. Furthermore, it examines existing studies that have employed lung organoids to evaluate the effects of cosmetic inhalation exposure, highlighting the potential of this approach to enhance the safety assessments of cosmetic products. We aim to establish lung organoids as a reliable tool for future research, ensuring the safety and regulatory compliance of cosmetics.

Keywords: cosmetics; inhalation exposure; lung organoids; risk assessment.

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Conflict of interest statement

Authors Xin Luo and Qi Xiang were employed by the company Biopharmaceutical R&D Center of Jinan University Co., Ltd. Author Rong Hu was employed by the company Shenzhen Hujia Technology Co., Ltd. Author Lifeng Tang was employed by the company Guangzhou Xika Technology Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Route for safety assessment of inhalation exposure.
Figure 2
Figure 2
Cell types of human lung organoids.
Figure 3
Figure 3
Different differentiation pathways of organoids induced by hPSCs.
See this image and copyright information in PMC

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