Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jun 12;12(6):762.
doi: 10.3390/children12060762.

Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis

Moreyba Borges-Luján  1 , Gloria Galán-Henríquez  1 , Rosa I Rodríguez-Viera  1 , František Bartoš  2 , Gema E González-Luis  1 , Eduardo Villamor  3
Affiliations
Review

Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis

Moreyba Borges-Luján et al. Children (Basel). .

Abstract

Background/Objectives: Prenatal adverse events may influence the development of complications of prematurity, including patent ductus arteriosus (PDA). We conducted a systematic review and Bayesian model-averaged (BMA) meta-analysis of observational studies exploring the association between hypertensive disorders of pregnancy (HDP) and the risk of PDA in preterm infants. Methods: PubMed/Medline and Embase databases were searched. We used BMA analysis to calculate Bayes factors (BFs). The BF10 is the ratio of the probability of the data under the alternative hypothesis (H1, presence of association) over the probability of the data under the null hypothesis (H0, absence of association). Results: We included 41 studies (58,004 infants). BMA analysis showed moderate evidence in favour of H0 for the association between HDP and any PDA (BF10 = 0.20) as well as for the association between HDP and hemodynamically significant PDA (BF10 = 0.27). Subgroup analyses based on the subtype of HDP showed that the moderate evidence in favour of H0 was only conclusive (i.e., BF10 < 0.33) for the associations of any PDA with preeclampsia (BF10 = 0.30) and hemodynamically significant PDA with preeclampsia (BF10 = 0.17). Conclusions: The currently available evidence suggests a lack of association between HDP and the risk of developing PDA.

Keywords: Bayesian statistics; meta-analysis; patent ductus arteriosus; preeclampsia; preterm infant.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of the systematic search.
Figure 2
Figure 2
Bayesian model-averaged (BMA) meta-analysis of the association between hypertensive disorders of pregnancy and any patent ductus arteriosus in preterm infants [24,27,28,30,35,37,42,43,45,47,49,51,52,54,57,61,63].
Figure 3
Figure 3
Bayesian model-averaged (BMA) meta-analysis of the association between hypertensive disorders of pregnancy and hemodynamically significant patent ductus arteriosus in preterm infants [25,26,29,31,32,33,34,36,38,39,40,41,44,46,47,48,50,53,55,56,58,59,60,62,64].
Figure 4
Figure 4
Bayesian model-averaged meta-regression (BMA-reg). Meta-regression plot showing the correlation between the effect size (log OR) of the association between hypertensive disorders of pregnancy and (A) any patent ductus arteriosus and (B) hemodynamically significant ductus arteriosus and the difference in gestational age (GA, exposed minus unexposed group in each individual study). The size of the circles is proportional to the contribution of each individual study to the association.
See this image and copyright information in PMC

References

    1. Reese J., Laughon M.M. The patent ductus arteriosus problem: Infants who still need treatment. J. Pediatr. 2015;167:954–956. doi: 10.1016/j.jpeds.2015.08.023. - DOI - PMC - PubMed
    1. Gillam-Krakauer M., Reese J. Diagnosis and management of patent ductus arteriosus. Neoreviews. 2018;19:e394–e402. doi: 10.1542/neo.19-7-e394. - DOI - PMC - PubMed
    1. Deshpande P., Baczynski M., McNamara P.J., Jain A., editors. Seminars in Fetal and Neonatal Medicine. Elsevier; Amsterdam, The Netherlands: 2018. Patent ductus arteriosus: The physiology of transition. - DOI - PubMed
    1. Hamrick S.E., Sallmon H., Rose A.T., Porras D., Shelton E.L., Reese J., Hansmann G. Patent ductus arteriosus of the preterm infant. Pediatrics. 2020;146:e20201209. doi: 10.1542/peds.2020-1209. - DOI - PMC - PubMed
    1. Agache I., Akdis C.A. Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases. J. Clin. Investig. 2019;129:1493–1503. doi: 10.1172/JCI124611. - DOI - PMC - PubMed

LinkOut - more resources