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. 2025 Jun 13;15(12):1504.
doi: 10.3390/diagnostics15121504.

Study of MicroRNA-192 as an Early Biomarker for Diagnosis of Diabetic Nephropathy

Mohamad Motawea  1 , Mayada S Khalel  2 , Ismail Kandil  3 , Ahmed Mohsen Faheem  4 , Maysaa El Sayed Zaki  5 , Mostafa Abdelsalam  6   7 , Fady Kyrillos  1
Affiliations

Study of MicroRNA-192 as an Early Biomarker for Diagnosis of Diabetic Nephropathy

Mohamad Motawea et al. Diagnostics (Basel). .

Abstract

Background/Objectives: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus. This clinical condition is diagnosed through the detection of microalbuminuria. Molecular biomarkers such as MicroRNA-192 may play a role in the early diagnosis of this condition. This study aims to compare the serum concentrations of MicroRNA-192 in diabetic patients with and without DN and in healthy individuals. Methods: This study was a retrospective case-control study that included three groups. Group I included diabetic patients without DN, Group II included patients with DN, and Group III included healthy control subjects. Blood samples were obtained from each participant and subjected to a full biochemical study including creatinine, albumin, and the detection of MicroRNA-192 by real-time polymerase chain reaction. Results: There were significant differences among the MicroRNA-192 levels in the three groups (p-0.001). There was a significant increase in the MicroRNA-192 level in Group I (1.35 ± 7 0.5) compared with Group II (0.65 ± 7 0.2, p3 = 0.001) and Group III (0.83 ± 7 0.3, p1-0.001). There was a significant reduction in the MicroRNA-192 level in Group II compared with Group III (p2-0.001). Conclusions: This study highlights the potential role of serum miR-192 as a noninvasive biomarker for the early detection of DN in patients with type 2 DM. Our findings demonstrated that serum miR-192 levels were significantly reduced in patients with DN compared with diabetic patients without nephropathy and healthy controls, suggesting the possible protective role of miR-192 in early disease stages.

Keywords: DM type 2; MicroRNA-192; albuminuria; diabetic nephropathy; eGFR.

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Conflict of interest statement

There are no conflicts of interest for any of the authors.

Figures

Figure 2
Figure 2
ROC curve for the MicroRNA 192 cutoff value to discriminate between Group I (DM without DN) and Group III (Control).
Figure 3
Figure 3
ROC curve for the MicroRNA 192 cutoff value to discriminate between Group II (DM with DN) and Group I (DM without DN).
Figure 4
Figure 4
ROC curve for the MicroRNA 192 cutoff value to discriminate between Group II (DM with DN) and Group III (Control).
Figure 1
Figure 1
Boxplot for MicroRNA 192 in the three groups.
See this image and copyright information in PMC

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