Homocysteinylation of Fibrinogen: A Post-Translational Link to Thrombosis
- PMID: 40564934
- PMCID: PMC12193665
- DOI: 10.3390/ijms26125471
Homocysteinylation of Fibrinogen: A Post-Translational Link to Thrombosis
Abstract
Homocysteinylation, a post-translational modification involving the covalent attachment of homocysteine to proteins, has emerged as a critical mechanism linking hyperhomocysteinemia to thrombotic disease. This review focuses on the homocysteinylation of fibrinogen, a key coagulation factor, and its impact on clot structure and function. Evidence indicates that elevated homocysteine levels can induce significant changes in fibrin architecture, promoting the formation of dense, rigid clots with reduced permeability and impaired fibrinolytic susceptibility, thus fostering a prothrombotic environment. However, inconsistencies in reported effects on fiber diameter and polymerization kinetics highlight the need for standardized experimental protocols. Advances in proteomics and high-resolution imaging are expected to clarify the molecular underpinnings of these modifications. Moreover, homocysteinylation intersects with oxidative stress and may serve as a mechanistic bridge between metabolic and vascular dysfunction. Understanding its role not only enhances insight into thrombosis but also opens avenues for biomarker discovery and targeted therapies in cardiovascular and potentially neurological disorders.
Keywords: fibrinogen; homocysteine; homocysteinylation; oxidation; oxidative stress; thrombosis.
Conflict of interest statement
The authors declare no conflicts of interest.
Figures
Similar articles
-
Home treatment for mental health problems: a systematic review.Health Technol Assess. 2001;5(15):1-139. doi: 10.3310/hta5150. Health Technol Assess. 2001. PMID: 11532236
-
Homocysteine-lowering interventions for preventing cardiovascular events.Cochrane Database Syst Rev. 2017 Aug 17;8(8):CD006612. doi: 10.1002/14651858.CD006612.pub5. Cochrane Database Syst Rev. 2017. PMID: 28816346 Free PMC article.
-
Psychological interventions for adults who have sexually offended or are at risk of offending.Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD007507. doi: 10.1002/14651858.CD007507.pub2. Cochrane Database Syst Rev. 2012. PMID: 23235646 Free PMC article.
-
Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid antibodies.Cochrane Database Syst Rev. 2018 Jul 13;7(7):CD012534. doi: 10.1002/14651858.CD012534.pub2. Cochrane Database Syst Rev. 2018. PMID: 30004572 Free PMC article.
-
Reactive Nitrogen Species and Fibrinogen: Exploring the Effects of Nitration on Blood Clots.Antioxidants (Basel). 2025 Jul 4;14(7):825. doi: 10.3390/antiox14070825. Antioxidants (Basel). 2025. PMID: 40722929 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical