Effects of genetic obesity on renal structure and function in the Zucker rat
- PMID: 4056570
Effects of genetic obesity on renal structure and function in the Zucker rat
Abstract
Although hyperphagia and obesity in the Zucker rat strain have been reported to be associated with spontaneous focal glomerulosclerosis (FGS), little is known about the age of onset and the natural history of hypertension, albuminuria, renal function, and glomerular injury in this model. We systematically investigated renal structure and function in obese male Zucker rats. Lean male littermates were used as controls. Obese rats developed glomerular mesangial matrix expansion and albuminuria by 14 weeks of age. These changes occurred despite normal inulin clearance (2.2 +/- 0.6 ml/min obese vs. 2.0 +/- 0.4 ml/min lean, P greater than 0.1) and filtration fraction (0.32 +/- 0.08 obese vs. 0.34 +/- 0.06 lean, P greater than 0.1), suggesting that increased glomerular filtration and renal plasma flow were not a prerequisite for the development of FGS. By 28 weeks of age, FGS was evident in seven of eight obese rats, and at 68 weeks of age all obese rats had marked FGS. Mean systolic blood pressure was elevated by 11 to 25 mm Hg in obese rats at all ages. Although the pathogenesis of glomerular injury is unknown, our data demonstrate that microalbuminuria, mild hypertension, and mesangial matrix expansion precede the development of progressive FGS in obese Zucker rats.
Similar articles
-
Effects of genetic obesity on renal structure and function in the Zucker rat. II. Micropuncture studies.J Lab Clin Med. 1985 Nov;106(5):605-10. J Lab Clin Med. 1985. PMID: 4056571
-
Renal hemodynamic and histological consequences of diets high in unsaturated fat, protein or sucrose in obese Zucker rats.Clin Nephrol. 1995 Feb;43(2):122-30. Clin Nephrol. 1995. PMID: 7736674
-
Hyperphagia as a mediator of renal disease initiation in obese Zucker rats.Obes Res. 2001 Aug;9(8):492-9. doi: 10.1038/oby.2001.64. Obes Res. 2001. PMID: 11500530
-
Glomerular adaptations to renal injury: the role of capillary hypertension in the pathogenesis of focal and segmental glomerulosclerosis.Adv Nephrol Necker Hosp. 1988;17:15-26. Adv Nephrol Necker Hosp. 1988. PMID: 3124537 Review. No abstract available.
-
Glomerular adaptations to renal injury or ablation. Role of capillary hypertension in the pathogenesis of progressive glomerulosclerosis.Blood Purif. 1988;6(4):230-9. doi: 10.1159/000169549. Blood Purif. 1988. PMID: 3061399 Review.
Cited by
-
Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy.Am J Physiol Renal Physiol. 2015 Nov 1;309(9):F791-9. doi: 10.1152/ajprenal.00211.2015. Epub 2015 Jun 24. Am J Physiol Renal Physiol. 2015. PMID: 26109088 Free PMC article.
-
Effects of xanthine oxidase inhibition with febuxostat on the development of nephropathy in experimental type 2 diabetes.Br J Pharmacol. 2016 Sep;173(17):2573-88. doi: 10.1111/bph.13527. Epub 2016 Jul 27. Br J Pharmacol. 2016. PMID: 27238746 Free PMC article.
-
Leptin receptor interacts with rat chromosome 1 to regulate renal disease traits.Physiol Genomics. 2012 Nov 1;44(21):1052-62. doi: 10.1152/physiolgenomics.00134.2011. Epub 2012 Sep 11. Physiol Genomics. 2012. PMID: 22968639 Free PMC article.
-
Antioxidant diet and sex interact to regulate NOS isoform expression and glomerular mesangium proliferation in Zucker diabetic rat kidney.Acta Histochem. 2016 Mar;118(2):183-93. doi: 10.1016/j.acthis.2015.12.011. Epub 2016 Jan 18. Acta Histochem. 2016. PMID: 26797190 Free PMC article.
-
Prevalence and risk factors of microalbuminuria in Thai nondiabetic hypertensive patients.Vasc Health Risk Manag. 2010 Mar 24;6:157-65. doi: 10.2147/vhrm.s9739. Vasc Health Risk Manag. 2010. PMID: 20448800 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical