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. 2025 Jun 11:15:1545829.
doi: 10.3389/fonc.2025.1545829. eCollection 2025.

Prevalence of precancerous cervical lesions and associated factors among HIV-positive women in Zewditu Memorial Hospital, Addis Ababa, Ethiopia

Abebech Haile Dinberia  1 , Habtamu Molla Ayele  2 , Meaza Zeleke Wodajo  3
Affiliations

Prevalence of precancerous cervical lesions and associated factors among HIV-positive women in Zewditu Memorial Hospital, Addis Ababa, Ethiopia

Abebech Haile Dinberia et al. Front Oncol. .

Abstract

Background: Cervical cancer is one of the major causes of morbidity and mortality among women in low- and middle-income countries. This problem is more severe in developing countries than in developed countries. This study was designed to identify the prevalence and determinants of precancerous cervical lesions among HIV-positive women in the Zewditu Memorial Hospital, Addis Ababa, Ethiopia.

Objective: This study aimed to assess the prevalence of precancerous cervical lesions and associated factors among HIV-positive women in Zewditu Memorial Hospital, Addis Ababa, Ethiopia.

Methods: An institution-based, cross-sectional, quantitative study was conducted. The sample size for the study was 361, which was calculated using a single population proportion method, and the final study participants were HIV-positive clients who were eligible for cervical cancer screening and selected using a simple random sampling method. Data were collected from each study participant using an interviewer-administered questionnaire. Data were then entered into Epi Info version 7, cleaned, and analyzed using SPSS version 25. Bivariable and multivariable logistic regression analyses were used to examine the relationship or statistical association between the independent and dependent variables, and odds ratios with 95% confidence intervals were computed.

Results: A total of 361 women who had follow-ups at an antiretroviral therapy clinic were included in the study. The prevalence of precancerous cervical lesions was 16.6%. Having a history of sexually transmitted disease [adjusted odds ratio (AOR) = 4.88, 95% confidence interval (CI): 1.66-14.36, p-value = 0.004], a history of smoking (AOR = 9.35, 95% CI: 3.15-27.75, p-value = 0.000), and abortion (AOR = 3.23, 95% CI: 1.58-6.58, p-value = 0.001) were significantly associated with precancerous cervical lesions.

Conclusion and recommendations: The prevalence of precancerous cervical lesions in this study was high. A history of abortion, smoking, and sexually transmitted infections were strongly associated with precancerous cervical lesions among women with human immunodeficiency virus. Hence, it is important to emphasize the importance of preventing sexually transmitted infections and repeated abortions, as well as discouraging cigarette smoking.

Keywords: Addis Ababa; Ethiopia; HIV; HPV; cervical cancer; precancerous cervical lesions.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Sampling technique and procedures for determining the prevalence of precancerous cervical lesions and associated factors among HIV-positive women aged 15–49– years in Zewditu Memorial Hospital, Addis Ababa, Ethiopia.
Figure 2
Figure 2
Prevalence of precancerous cervical cancer lesion at Zewditu Memorial Hospital, Addis Ababa, Ethiopia 2022.
See this image and copyright information in PMC

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References

    1. Ibeanu OA. Molecular pathogenesis of cervical cancer. Cancer Biol Ther. (2011) 11:295–306. doi: 10.4161/cbt.11.3.14686 - DOI - PubMed
    1. Olusola P, Banerjee HN, Philley JV, Dasgupta S. Human papilloma virus-associated cervical cancer and health disparities. Cells. (2019) 8:622. doi: 10.3390/cells8060622 - DOI - PMC - PubMed
    1. World Health Organization . Strategic framework for the comprehensive prevention and control of cervical cancer in the Western Pacific Region 2023-2030. Geneva: World Health Organization; (2023).
    1. Weldegebreal F, Worku T. Precancerous cervical lesion among HIV-positive women in Sub-Saharan Africa: a systematic review and meta-analysis. Cancer Control. (2019) 26:1073274819845872. doi: 10.1177/1073274819845872 - DOI - PMC - PubMed
    1. Lemu LG, Woldu BF, Teke NE, Bogale ND, Wondimenew EA. Precancerous cervical lesions among HIV-Infected women attending HIV Care and Treatment clinics in Southwest Ethiopia: a cross-sectional study. Int J Women’s Health. (2021) 3:297–303. doi: 10.2147/IJWH.S295137 - DOI - PMC - PubMed

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