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Review
. 2025 May 26;17(5):e84828.
doi: 10.7759/cureus.84828. eCollection 2025 May.

Intracranial Aneurysm Predisposing to Terson's Syndrome: Insights From a Systematic Review

Ali K Al-Shalchy  1 , Ahmed S Al-Wassiti  1
Affiliations
Review

Intracranial Aneurysm Predisposing to Terson's Syndrome: Insights From a Systematic Review

Ali K Al-Shalchy et al. Cureus. .

Abstract

Terson syndrome (TS) is an intraocular hemorrhage associated with subarachnoid hemorrhage (SAH), often linked to specific intracranial aneurysm locations. This review and meta-analysis aim to explore the relationship between aneurysm location and the risk of developing TS. A systematic search was conducted using PubMed and Scopus with the terms "Terson's Syndrome" OR "Terson Syndrome." Studies involving adult patients in English were included. Data on aneurysm location, TS incidence, and clinical outcomes were extracted. The risk of bias was assessed using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool and the Case Report (CARE) guidelines. Meta-analysis was performed using Microsoft Excel 2016 (Microsoft® Corp., Redmond, WA, USA). Twenty-one studies with 201 patients were analyzed. Aneurysms in the posterior communicating artery (Pcom) were most frequently associated with TS (24.48%), followed by the anterior communicating artery (Acom) (23.87%). Endovascular coiling was the most common treatment (67.83%), with vitrectomy leading to improved visual outcomes. Aneurysms in the anterior circulation are strongly linked to TS. Early detection and timely surgical interventions, such as vitrectomy, are crucial for improving visual and clinical outcomes in patients with TS.

Keywords: aneurysm location; intraocular hemorrhage; subarachnoid hemorrhage; terson syndrome; vitrectomy.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. PRISMA Flowchart of the Included Studies
PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses
See this image and copyright information in PMC

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References

    1. Pathogenesis of Terson syndrome. Hayreh SS. Indian J Ophthalmol. 2022;70:4130–4137. - PMC - PubMed
    1. Terson syndrome - clinical presentation, management, and visual outcomes in a tertiary centre. Lima-Fontes M, Leuzinger-Dias M, Rodrigues R, et al. Clin Ophthalmol. 2023;17:351–359. - PMC - PubMed
    1. An explanation for Terson syndrome at last: the glymphatic reflux theory. Kumaria A, Gruener AM, Dow GR, Smith SJ, Macarthur DC, Ingale HA. J Neurol. 2022;269:1264–1271. - PubMed
    1. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Page MJ, McKenzie JE, Bossuyt PM, et al. BMJ. 2021;372:0. - PMC - PubMed
    1. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. Sterne JA, Hernán MA, Reeves BC, et al. BMJ. 2016;355:0. - PMC - PubMed

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