Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Practice Guideline
. 2025 Aug;27(8):101454.
doi: 10.1016/j.gim.2025.101454. Epub 2025 Jun 23.

ACMG SF v3.3 list for reporting of secondary findings in clinical exome and genome sequencing: A policy statement of the American College of Medical Genetics and Genomics (ACMG)

Kristy Lee  1 , Noura S Abul-Husn  2 , Laura M Amendola  3 , Kyle B Brothers  4 , Wendy K Chung  5 , Michael H Gollob  6 , Adam S Gordon  7 , Steven M Harrison  8 , Ray E Hershberger  9 , Marilyn Li  10 , Deborah Ondrasik  11 , C Sue Richards  12 , Andrew Stergachis  13 , Douglas R Stewart  14 , Christa Lese Martin  15 , David T Miller  16 ; ACMG Secondary Findings Working Group. Electronic address: documents@acmg.net  17
Affiliations
Practice Guideline

ACMG SF v3.3 list for reporting of secondary findings in clinical exome and genome sequencing: A policy statement of the American College of Medical Genetics and Genomics (ACMG)

Kristy Lee et al. Genet Med. 2025 Aug.
No abstract available

Keywords: Exome sequencing; Genome sequencing; Incidental findings; Secondary findings.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Funding and support listed here did not support development of this document unless included in the acknowledgments section. Kristy Lee, Laura M. Amendola, Kyle B. Brothers, Wendy K. Chung, Michael H. Gollob, Steven M. Harrison, Ray E. Hershberger, Marilyn Li, Deborah Ondrasik, Douglas R. Stewart, C. Sue Richards, Andrew Stergachis, and David T. Miller receive salary for providing clinical services that may be relevant to the content of this document in either the laboratory or patient care setting at their listed affiliations. The following workgroup members have additional conflicts of interest: Kristy Lee receives grant funding from Janssen Pharmaceuticals and Foundation Fighting Blindness. Noura S. Abul-Husn is an employee and equity holder of 23andMe and serves as a scientific advisory board member for Allelica. Kyle B. Brothers receives in-kind research support from Invitae Corp. Wendy K. Chung is a member of the scientific advisory board of Regeneron Genetics Center and on the Board of Directors of Prime Medicine. Douglas R. Stewart is supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics of the National Cancer Institute, Rockville, MD, and also performs contract clinical telehealth services for Genome Medical, Inc, in accordance with relevant NCI ethics policies. All other authors declare no additional conflicts of interest.

References

    1. Green RC, Berg JS, Grody WW, et al. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genet Med. 2013;15(7):565–574. 10.1038/gim.2013.73 - DOI - PMC - PubMed
    1. Kalia SS, Adelman K, Bale SJ, et al. Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics. Genet Med. 2017;19(2):249–255. 10.1038/gim.2016.190 - DOI - PubMed
    1. Miller DT, Lee K, Gordon AS, et al. Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2021 update: a policy statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2021;23(8):1391–1398. 10.1038/s41436-021-01171-4 - DOI - PMC - PubMed
    1. Miller DT, Lee K, Chung WK, et al. ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med 2021;23(8):1381–1390. 10.1038/s41436-021-01172-3 - DOI - PubMed
    1. Miller DT, Lee K, Abul-Husn NS et al. ACMG SF v3.1 list for reporting of secondary findings in clinical exome and genome sequencing: A policy statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med 2022;24(7):1407–1414. 10.1016/j.gim.2022.04.006 - DOI - PubMed

Publication types

LinkOut - more resources