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Review
. 2025 Jun 26;52(1):639.
doi: 10.1007/s11033-025-10770-2.

Potential use of plant secondary metabolites in the treatment of allergic respiratory diseases (ARDs)

Miran Kang  1 , Kwang Mo Yang  2   3 , Christine Stanly  4 , Alina Pant  4
Affiliations
Review

Potential use of plant secondary metabolites in the treatment of allergic respiratory diseases (ARDs)

Miran Kang et al. Mol Biol Rep. .

Abstract

The occurrence of allergic respiratory diseases (ARDs) is increasing worldwide due to hypersensitivity to foreign allergens. Around 40% of the global population is affected by ARDs which are exacerbated by environmental pollution. Furthermore, prolonged ARDs-associated symptoms reduce quality of life and increase the risk of neurological disorders like depression, anxiety disorder, and dementia through oxidative stress-induced neuroinflammation. Recently, plant secondary metabolites (PSMs) have emerged as novel dietary therapeutics, which exhibit potent antioxidant and antiallergic capabilities in treating ARDs. These bioactive compounds, have antimicrobial, antiviral, and antiallergic properties, making them particularly useful in treating respiratory diseases. This review summarizes and discusses the mechanisms of ARDs and how PSMs could be alternative therapeutics for treating ARDs, as well as prospects.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

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References

    1. Holloway JW, Yang IA, Holgate ST (2010) Genetics of allergic disease. J Allergy Clin Immunol 125:S81–S94. https://doi.org/10.1016/j.jaci.2009.10.071
    1. Pavón-Romero GF, Calderón-Ezquerro MDC, Rodríguez-Cervantes MA, Fernández-Villanueva D, Melgoza-Ruiz E, Ramírez-Jiménez F, Teran LM (2022) Association of allergic sensitivity and pollination in allergic respiratory disease: the role of pollution. J Asthma Allergy 15:1227–1243. https://doi.org/10.2147/jaa.S373307 - DOI - PubMed - PMC
    1. Manisalidis I, Stavropoulou E, Stavropoulos A, Bezirtzoglou E (2020) Environmental and health impacts of air pollution: A review. Front Public Health 8:14. https://doi.org/10.3389/fpubh.2020.00014 - DOI - PubMed - PMC
    1. Gutman L, Pauly V, Papazian L, Roch A (2023) Effects of ambient air pollutants on ARDS incidence and outcome: a narrative review. Ann Intensive Care 13:84. https://doi.org/10.1186/s13613-023-01182-1 - DOI - PubMed - PMC
    1. Pöschl U, Shiraiwa M (2015) Multiphase chemistry at the atmosphere–biosphere interface influencing climate and public health in the anthropocene. Chem Rev 115:4440–4475. https://doi.org/10.1021/cr500487s - DOI - PubMed

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