An AI model of transplantation risk for myelofibrosis
- PMID: 40569639
- PMCID: PMC7618513
- DOI: 10.1182/blood.2025028816
An AI model of transplantation risk for myelofibrosis
Abstract
Allogeneic hematopoietic cell transplantation (allo-HCT) remains to be the only curative treatment for myelofibrosis (MF) but is associated with significant toxicity; it is therefore crucial to identify high-risk patients who might benefit from alternative therapies. In this issue of Blood, Hernández-Boluda et al. develop an improved machine-learning-based model and web-based application to predict high risk of allo-HCT for the treatment of MF.
Conflict of interest statement
Conflict-of-interest disclosure: S.M.-F, declares no competing financial interests.
Comment on
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Use of machine learning techniques to predict poor survival after hematopoietic cell transplantation for myelofibrosis.Blood. 2025 Jun 26;145(26):3139-3152. doi: 10.1182/blood.2024027287. Blood. 2025. PMID: 40145857
References
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- Hernández-Boluda JC, Mosquera-Orgueira A, Gras L, et al. Prediction of Poor Survival after Hematopoietic Cell Transplantation in Myelofibrosis Using Machine Learning Techniques. Blood. 2025 - PubMed
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- Méndez-Ferrer S, Fang Z. In: Encyclopedia of Cell Biology. Second Edition. Bradshaw RA, Hart GW, Stahl PD, editors. Oxford: Academic Press; 2023. Myeloproliferative Neoplasms; pp. 696–711.
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- Kroger N, Bacigalupo A, Barbui T, et al. Indication and management of allogeneic haematopoietic stem-cell transplantation in myelofibrosis: updated recommendations by the EBMT/ELN International Working Group. Lancet Haematol. 2024;11(1):e62–e74. - PubMed
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- Gagelmann N, Ditschkowski M, Bogdanov R, et al. Comprehensive clinical-molecular transplant scoring system for myelofibrosis undergoing stem cell transplantation. Blood. 2019;133(20):2233–2242. - PubMed
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