HIV Post Exposure Prophylaxis: prospects, opportunities and challenges

doi:10.1002/jia2.26511

Editorial

. 2025 Jun;28 Suppl 1(Suppl 1):e26511.

doi: 10.1002/jia2.26511.

HIV Post Exposure Prophylaxis: prospects, opportunities and challenges

Julie Fox^{1

2}, Euphemia L Sibanda^{3

4}, Peter Godfrey-Faussett⁵

Affiliations

¹ King's College London, London, UK.
² Guys and St Thomas's NHS Foundation Trust, London, UK.
³ Centre for Sexual Health and HIV/AIDS Research (CeSHHAR), Harare, Zimbabwe.
⁴ Liverpool School of Tropical Medicine, Liverpool, UK.
⁵ Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.

PMID: 40569861
PMCID: PMC12231641
DOI: 10.1002/jia2.26511

Editorial

HIV Post Exposure Prophylaxis: prospects, opportunities and challenges

Julie Fox et al. J Int AIDS Soc. 2025 Jun.

. 2025 Jun;28 Suppl 1(Suppl 1):e26511.

doi: 10.1002/jia2.26511.

Authors

Julie Fox^{1

2}, Euphemia L Sibanda^{3

4}, Peter Godfrey-Faussett⁵

Affiliations

¹ King's College London, London, UK.
² Guys and St Thomas's NHS Foundation Trust, London, UK.
³ Centre for Sexual Health and HIV/AIDS Research (CeSHHAR), Harare, Zimbabwe.
⁴ Liverpool School of Tropical Medicine, Liverpool, UK.
⁵ Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.

PMID: 40569861
PMCID: PMC12231641
DOI: 10.1002/jia2.26511

No abstract available

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Conflict of interest statement

AUTHORS’ CONTRIBUTIONS

JF and ELS contributed to the initial draft of the manuscript. PG‐F provided feedback, reviewed and edited the draft, and approved the final version prior to submission.

References

1. UNAIDS . Fact Sheet 2024: Global HIV Statistics. Geneva: UNAIDS; 2024.
1. UNAIDS . 2024 Global AIDS Update: The Urgency of Now—AIDS at a Crossroads. Geneva: UNAIDS; 2024.
1. Otten RA, Smith DK, Adams DR, Pullium JK, Jackson E, Kim CN, et al. Efficacy of postexposure prophylaxis after intravaginal exposure of pig‐tailed macaques to a human‐derived retrovirus (human immunodeficiency virus type 2). J Virol. 2000;74(20):9771–5. - PMC - PubMed
1. Tsai C‐C, Emau P, Follis KE, Beck TW, Benveniste RE, Bischofberger N, et al. Effectiveness of postinoculation (R)‐9‐(2‐phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment. J Virol. 1998;72(5):4265–73. - PMC - PubMed
1. Irvine C, Egan KJ, Shubber Z, Van Rompay KK, Beanland RL, Ford N. Efficacy of HIV postexposure prophylaxis: systematic review and meta‐analysis of nonhuman primate studies. Clin Infect Dis. 2015;60 Suppl 3:S165–9. - PubMed

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[1] UNAIDS . Fact Sheet 2024: Global HIV Statistics. Geneva: UNAIDS; 2024.

[2] UNAIDS . Fact Sheet 2024: Global HIV Statistics. Geneva: UNAIDS; 2024.

[3] UNAIDS . 2024 Global AIDS Update: The Urgency of Now—AIDS at a Crossroads. Geneva: UNAIDS; 2024.

[4] UNAIDS . 2024 Global AIDS Update: The Urgency of Now—AIDS at a Crossroads. Geneva: UNAIDS; 2024.

[5] Otten RA, Smith DK, Adams DR, Pullium JK, Jackson E, Kim CN, et al. Efficacy of postexposure prophylaxis after intravaginal exposure of pig‐tailed macaques to a human‐derived retrovirus (human immunodeficiency virus type 2). J Virol. 2000;74(20):9771–5. - PMC - PubMed

[6] Otten RA, Smith DK, Adams DR, Pullium JK, Jackson E, Kim CN, et al. Efficacy of postexposure prophylaxis after intravaginal exposure of pig‐tailed macaques to a human‐derived retrovirus (human immunodeficiency virus type 2). J Virol. 2000;74(20):9771–5. - PMC - PubMed

[7] Tsai C‐C, Emau P, Follis KE, Beck TW, Benveniste RE, Bischofberger N, et al. Effectiveness of postinoculation (R)‐9‐(2‐phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment. J Virol. 1998;72(5):4265–73. - PMC - PubMed

[8] Tsai C‐C, Emau P, Follis KE, Beck TW, Benveniste RE, Bischofberger N, et al. Effectiveness of postinoculation (R)‐9‐(2‐phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment. J Virol. 1998;72(5):4265–73. - PMC - PubMed

[9] Irvine C, Egan KJ, Shubber Z, Van Rompay KK, Beanland RL, Ford N. Efficacy of HIV postexposure prophylaxis: systematic review and meta‐analysis of nonhuman primate studies. Clin Infect Dis. 2015;60 Suppl 3:S165–9. - PubMed

[10] Irvine C, Egan KJ, Shubber Z, Van Rompay KK, Beanland RL, Ford N. Efficacy of HIV postexposure prophylaxis: systematic review and meta‐analysis of nonhuman primate studies. Clin Infect Dis. 2015;60 Suppl 3:S165–9. - PubMed

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HIV Post Exposure Prophylaxis: prospects, opportunities and challenges

Affiliations

HIV Post Exposure Prophylaxis: prospects, opportunities and challenges

Authors

Affiliations

Conflict of interest statement

AUTHORS’ CONTRIBUTIONS

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References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources