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Review
. 2025 Aug;11(8):713-715.
doi: 10.1016/j.trecan.2025.06.006. Epub 2025 Jun 25.

Transcriptional regulation of cuproptosis resistance in cancer therapy

Daolin Tang  1 , Rui Kang  2
Affiliations
Review

Transcriptional regulation of cuproptosis resistance in cancer therapy

Daolin Tang et al. Trends Cancer. 2025 Aug.

Abstract

Cuproptosis is a newly identified form of copper-dependent cell death. Recent studies show that solid tumors evade this process through transcriptional reprogramming, including hypoxia inducible factor 1 subunit alpha (HIF1A) and NFE2 like BZIP transcription factor 2 (NFE2L2) activation and BTB domain and CNC homolog 1 (BACH1) suppression. Targeting these pathways may restore cuproptosis sensitivity, offering a promising strategy to overcome therapy resistance in cancer.

Keywords: copper metabolism; cuproptosis; therapy resistance; transcription factor; tumor metabolism.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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