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Review
. 2025 Jun 8;30(12):2512.
doi: 10.3390/molecules30122512.

Eleutherococcus senticosus (Acanthopanax senticosus): An Important Adaptogenic Plant

Grzegorz Kos  1 , Katarzyna Czarnek  2 , Ilona Sadok  3 , Agnieszka Krzyszczak-Turczyn  3 , Paweł Kubica  1 , Karolina Fila  4 , Gizem Emre  5 , Małgorzata Tatarczak-Michalewska  6 , Małgorzata Latalska  7 , Eliza Blicharska  6 , Daniel Załuski  8 , Nazım Şekeroğlu  9 , Agnieszka Szopa  1
Affiliations
Review

Eleutherococcus senticosus (Acanthopanax senticosus): An Important Adaptogenic Plant

Grzegorz Kos et al. Molecules. .

Abstract

This comprehensive review focuses on Eleutherococcus senticosus (ES), examining the phytochemical composition, traditional medicinal roles, ecological traits, and pharmacological effects. Native to Northeast Asia, ES is used in traditional Chinese, Korean, and Japanese medicine. The rhizomes and bark are utilized medicinally and valued for their adaptogenic properties that enhance stress resistance, boost mental and physical endurance, and exhibit immunostimulatory effects that strengthen the immune system. Its pharmacological potential stems from a variety of bioactive compounds, including eleutherosides, lignans, saponins, flavonoids, and polysaccharides, which contribute to health benefits such as neuroprotective, antidiabetic, anticancer, and antioxidative activities. Neuroprotective properties may aid in the management of neurodegenerative conditions, such as Alzheimer's and Parkinson's disease, while antidiabetic effects support glucose regulation and insulin sensitivity. With increasing demands and conservation concerns, sustainable cultivation practices are essential, as ES is endangered in some areas. Plant biotechnology techniques offer solutions to enhance secondary metabolite yields while ensuring genetic stability and minimizing environmental impacts. ES is a promising natural resource for various industries because of its extensive benefits. Still, its conservation and sustainable production are critical and require ongoing research and innovative cultivation strategies.

Keywords: Siberian ginseng; adaptogenic raw materials; biological activity; medicinal plants; phytochemical composition; utility of Eleutherococcus senticosus.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Key bioactive constituents of ES. The figure was prepared using Microsoft Office PowerPoint 2007.
Figure 2
Figure 2
Distribution of major bioactive constituents of ES by plant parts (the pink color indicates compounds classified as lignans, the light blue color indicates triterpene saponins, and the dark blue color indicates phenolic compounds). The figure was prepared using Microsoft Office Power Point 2007.
Figure 3
Figure 3
Chemical structure of phytochemicals characteristic of ES.
Figure 4
Figure 4
The juxtaposition of extraction parameters and purification conditions during the determination of polysaccharides, eleutherosides, and flavonoids.
See this image and copyright information in PMC

References

    1. Todorova V., Ivanov K., Delattre C., Nalbantova V., Karcheva-Bahchevanska D., Ivanova S. Plant Adaptogens—History and Future Perspectives. Nutrients. 2021;13:2861. doi: 10.3390/nu13082861. - DOI - PMC - PubMed
    1. Gerontakos S., Taylor A., Avdeeva A.Y., Shikova V.A., Pozharitskaya O.N., Casteleijn D., Wardle J., Shikov A.N. Findings of Russian Literature on the Clinical Application of Eleutherococcussenticosus (Rupr. & Maxim.): A Narrative Review. J. Ethnopharmacol. 2021;278:114274. - PubMed
    1. Flora of China Eleutherococcussenticosus. [(accessed on 4 January 2024)]. Available online: http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=220004653.
    1. Guo S., Wei H., Li J., Fan R., Xu M., Chen X., Wang Z. Geographical Distribution and Environmental Correlates of Eleutherosides and Isofraxidin in Eleutherococcussenticosus from Natural Populations in Forests at Northeast China. Forests. 2019;10:872. doi: 10.3390/f10100872. - DOI
    1. The World Flora Online’ WFO Eleutherococcussenticosus (Rupr. & Maxim.) Maxim. 2024. [(accessed on 31 January 2024)]. Available online: https://www.worldfloraonline.org/taxon/wfo-0000948117#B.

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