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. 2025 Jun 26.
doi: 10.1002/ehf2.15357. Online ahead of print.

Heart transplantation outcomes with donation after circulatory death in patients with left ventricular assist device

Aris Karatasakis  1 , Edwin Grajeda Silvestri  2 , Gatha G Nair  3 , Benjamin Zuniga  4 , Song Li  5 , Claudius Mahr  5 , Richard K Cheng  1 , April S Stempien-Otero  1 , Ioannis Dimarakis  6 , Maziar Khorsandi  6 , Jay D Pal  6 , Jorge R Kizer  7   8 , Marc A Simon  9 , Claudio A Bravo  5
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Free article

Heart transplantation outcomes with donation after circulatory death in patients with left ventricular assist device

Aris Karatasakis et al. ESC Heart Fail. .
Free article

Abstract

Aims: Donation after circulatory death (DCD) has emerged as a strategy to increase the donor pool for heart transplantation (HT). Left ventricular assist device (LVAD) patients represent a discrete and unique population. We sought to explore the early outcomes of DCD-HT compared with donation after brain death (DBD) HT in LVAD patients.

Methods and results: We obtained data from the United Network of Organ Sharing database. The main cohort consisted of adults listed for HT between 17 October 2018 and 3 July 2024, with LVAD implanted before or after listing. The primary outcome was survival within the first year post-HT. There were 3336 patients with LVAD underwent HT during the study period (median age 55 years (interquartile range 45-62), 24% women, 29% Black, 89% DBD). The short-term post-HT mortality in LVAD patients who underwent DCD HT was not significantly different from DBD (adjusted hazard ratio [aHR] 1.00, 95% CI 0.70-1.42, P value > 0.9). The likelihood of transplantation within 1 year was higher at centres performing DCD (aHR 1.44, 95% CI 1.39-1.49, P < 0.001). Despite the longer donor-recipient distance in DCD-HT, in-hospital outcomes (stroke and acute kidney injury requiring dialysis) were not different from DBD-HT. A higher incidence of primary graft dysfunction (adjusted risk ratio [aRR] 3.8, 95% CI 2.5-5.7, P < 0.001), and treated rejection was observed with DCD-HT (aRR 1.48, 95% CI 1.14-1.93, P = 0.003).

Conclusions: In LVAD patients who received DCD HT, early post-transplant survival, stroke, acute kidney injury and length of stay were not significantly different from those who underwent DBD HT. There were increased rates of primary graft dysfunction and treated rejection among LVAD patients who underwent DCD HT. Patients in a DCD centre were significantly more likely to be transplanted earlier.

Keywords: Donation after brain death; Donation after circulatory death; Heart transplantation; Left ventricular assist device.

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