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. 2025 Jun 19;15(6):105568.
doi: 10.5498/wjp.v15.i6.105568.

Risk factors for depression in patients in perimenopause with cervical cancer

Yuan Zhang  1 , Jing-Bo Liu  1 , Meng-Jun Liu  1 , Jing Liu  1 , Jing Zhang  2
Affiliations

Risk factors for depression in patients in perimenopause with cervical cancer

Yuan Zhang et al. World J Psychiatry. .

Abstract

Background: Cervical cancer is a significant health concern among females in perimenopause, with a high prevalence of depression in this population. The rationale for this study was to explore the risk factors associated with depression in patients in perimenopause with cervical cancer. We hypothesized that socioeconomic status, disease characteristics, and quality of life factors contributed to the development of depression in these patients.

Aim: To investigate the risk factors associated with depression in patients in perimenopause with cervical cancer.

Methods: A retrospective study was conducted on 254 patients in perimenopause with cervical cancer admitted to a single center. Patients were divided into a non-depression group (n = 152) and a depression group (n = 102) based on whether depression occurred after treatment. Data collection included demographic, clinical, and psychosocial factors. The Hamilton Depression Rating Scale was used to assess depression. Logistic regression analysis was performed to identify risk factors.

Results: Patients with depression more often had low income (< 4000 China yuan: 66.7% vs 6.6%, P < 0.001), initial disease onset (70.6% vs 57.2%, P = 0.001), low social support (70.6% vs 55.3%, P = 0.014), pathological stages III-IV (70.6% vs 41.5%, P < 0.001), high pain level (65.7% vs 34.2%, P < 0.001), and poor sleep quality (67.6% vs 32.2%, P < 0.001). Logistic regression identified low income [odds ratio (OR) = 32.606, P < 0.001], initial disease onset (OR = 4.282, P = 0.001), pathological stages III-IV (OR = 4.123, P = 0.0005), high pain level (OR = 1.181, P = 0.0000434), and poor sleep quality (OR = 3.094, P = 0.0041) as key risk factors.

Conclusion: Low income, initial onset, low support, advanced stages, high pain, and poor sleep quality increased depression risk in patients in perimenopause with cervical cancer. Studies investigating interventions for this population are needed.

Keywords: Cervical cancer; Depression; Perimenopause; Risk factors; Social support.

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Conflict of interest statement

Conflict-of-interest statement: All authors reported no relevant conflicts of interest for this article.

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