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. 2025 Jun 12:12:1484401.
doi: 10.3389/fcvm.2025.1484401. eCollection 2025.

Impact of cardiac rehabilitation and treatment compliance after ST-segment elevation myocardial infarction (STEMI) in France, the STOP SCA+ study

Emeline Laurent  1   2 , Lucile Godillon  1 , Marc-Florent Tassi  1   3 , Pierre Marcollet  4 , Stéphan Chassaing  5 , Marie Decomis  6 , Julien Bezin  7 , Christophe Laure  8 , Denis Angoulvant  9   10 , Grégoire Range  8 , Leslie Grammatico-Guillon  1   10
Affiliations

Impact of cardiac rehabilitation and treatment compliance after ST-segment elevation myocardial infarction (STEMI) in France, the STOP SCA+ study

Emeline Laurent et al. Front Cardiovasc Med. .

Abstract

Introduction: Acute ST-elevation myocardial infarction (STEMI) is a frequent and serious presentation of acute coronary syndrome. The STOP-SCA+ study aimed to (i) describe 1-year compliance to secondary prevention cardiac tri-therapy and (ii) identify factors associated with negative outcomes 1 year after STEMI, particularly the impact of compliance and rehabilitation care.

Methods: Patients who were >18 years old and hospitalized for STEMI in five interventional cardiac centers with the same cardiac registry in one French region (2.5 million inhabitants), between 2014 and 2018, were included. After a probabilistic matching with the National Health Insurance database [Système National des Données de Santé (SNDS), 96% matching], compliance for cardiac tri-therapy was studied: aspirin, P2Y12 inhibitor, and statin. Factors associated with poor outcomes (ischemic complications, death) were analyzed using Cox modeling and those for compliance by logistic regression.

Results: A total of 3,768 patients were included, of whom 84% underwent primary percutaneous coronary intervention. At 1 year, 3,362 had at least one tri-therapy delivery (89.2%), of whom 53% were compliant, and 2,478 patients went to cardiac rehabilitation (65.8%). Death occurred in 130 patients and/or ischemic complications in 194 (total of poor outcomes 8.0%). Compliance was not associated with complications over the year [HR 1.16 (0.86-1.57)], while the absence of cardiac rehabilitation [2.31 (1.73-3.08)] was associated, as well as female sex 1.54 (1.08-2.19), renal impairment [2.87 (1.49-5.53)], initial STEMI clinical presentation [pejorative Killip 2.04 (1.19-3.50)], and LVEF <40% at discharge [2.22 (1.65-2.99)]. Additionally, cardiac rehabilitation was associated with compliance [OR 1.55 (1.34-1.79)].

Discussion: Pejorative outcomes 1 year after a STEMI represented 8% of cases, mainly related to patient features, the initial clinical presentation, and the absence of access to rehabilitation. Compliance part in patient health outcomes will need further modeling to accurately study its impact. Matching clinical and medico-administrative databases proved to be relevant for assessing outcomes at a large scale.

Keywords: cardiac rehabilitation; compliance; myocardial infarction (MI); outcome; probabilistic matching.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer EG declared a shared affiliation with the author JB to the handling editor at the time of review.

Figures

Figure 1
Figure 1
Cardiac drug compliance at 1 year after STEMI—the STOP-SCA+ study. PDC, proportion of days covered by the studied medication.
Figure 2
Figure 2
Factors associated with an ischemic complication and/or death at 1 year after STEMI—the STOP-SCA+ study. LVEF, left ventricular ejection fraction.
Figure 3
Figure 3
Factors associated with compliance for the cardiac tri-therapy (PDC ≥80%) at 1 year after STEMI—the STOP-SCA+ study. TCA, transluminal coronary angioplasty; GP, general practitioner.
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