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. 2025 Jun 25:9:25424823251352846.
doi: 10.1177/25424823251352846. eCollection 2025 Jan-Dec.

Insights into the role of cerebrospinal fluid cytokines in Alzheimer's disease: A commentary on recent findings

Carlo Manco  1 , Matteo Pardini  2   3 , Delia Righi  1 , Domenico Plantone  1
Affiliations

Insights into the role of cerebrospinal fluid cytokines in Alzheimer's disease: A commentary on recent findings

Carlo Manco et al. J Alzheimers Dis Rep. .

Abstract

We read the study by Bruno et al. (2025), which highlights the interplay between neuroinflammation and cortical activity in Alzheimer's disease (AD). Their findings on IL-4, IL-7, IL-8, and IL-12 levels and their association with EEG alterations complement our recent research on IL-6, GDF-15, and neuronal damage. We discuss the implications of IL-8 in blood-brain barrier permeability and neurodegeneration, the role of APOE4 in epilepsy-related phenotypes, and the need for better patient stratification. Future studies should explore these inflammatory pathways to clarify the relationship between neurodegeneration and interictal epileptiform discharges in AD.

Keywords: Alzheimer's disease; epilepsy; interleukins; neuroinflammation.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

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