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. 2025 Jun 12:16:1567716.
doi: 10.3389/fendo.2025.1567716. eCollection 2025.

Vitamin D deficiency and VDR TaqI polymorphism on diabetic nephropathy risk among type 2 diabetes patients

Addisu Melake  1 , Misganaw Asmamaw Mengstie  1
Affiliations

Vitamin D deficiency and VDR TaqI polymorphism on diabetic nephropathy risk among type 2 diabetes patients

Addisu Melake et al. Front Endocrinol (Lausanne). .

Abstract

Background: Many studies have shown that vitamin D deficiency and vitamin D receptor TaqI gene polymorphisms are associated with susceptibility to diabetic nephropathy in various populations. The objective of this study was to determine the impact of vitamin D deficiency and vitamin D receptor TaqI gene polymorphism on the risk of diabetic nephropathy complications in T2DM at the Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia.

Methods: A total of 210 participants, including 70 diabetic patients with nephropathy, 70 diabetic patients without nephropathy, and 70 healthy controls, participated in an age-and sex-matched hospital-based case-control study. Demographic and clinical data were assessed to determine the related risk factors. DNA was extracted from blood samples and subjected to polymerase chain reaction and agarose gel electrophoresis analysis to determine the TaqI genotypes.

Results: Vitamin D deficiency was detected in our investigation, and it was much more prevalent in diabetic nephropathy patients than type 2 diabetic patients and controls (OR = 5.05, 95% CL = 2.03-12.53; P < 0.001). Moreover, both the TaqI tt genotype (OR: 2.48; 95% CL: 1.15-5.37; P=0.020) and t allele (OR: 1.70; 95% CL: 1.13-2.57; P=0.010) were substantially more prevalent in diabetic nephropathy patients than in type 2 diabetic patients and controls, indicating that it may be a major risk factor for the development of diabetic nephropathy.

Conclusions: The findings point to a potential link between vitamin D deficiency and diabetic nephropathy complications. Moreover, TaqI gene polymorphisms have been linked to an increased risk of developing the disease in the Ethiopian population under study.

Keywords: Ethiopia; TaqI; diabetic nephropathy; type 2 diabetes mellitus; vitamin D deficiency.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Distribution of the vitamin D deficiency among DN, T2DM, and controls.
Figure 2
Figure 2
Distribution of the TaqI genotype among DN, T2DM, and controls.
See this image and copyright information in PMC

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