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. 2025 Mar 11;16(2):225-232.
doi: 10.22088/cjim.16.2.225. eCollection 2025 Spring.

Systematic review and meta-analysis of the association between biofilm formation and antibiotic resistance in MRSE Isolated from Iranian patients

Parisa Behshood  1 , Elahe Tajbakhsh  1
Affiliations

Systematic review and meta-analysis of the association between biofilm formation and antibiotic resistance in MRSE Isolated from Iranian patients

Parisa Behshood et al. Caspian J Intern Med. .

Abstract

Background: Biofilms are organized communities of microorganisms encased in a self-produced matrix that adheres to surfaces and can have both beneficial and detrimental effects in various environments. These biofilms have been linked to severe infections in humans. We investigated the association between antibiotic resistance and biofilm formation in methicillin-resistant Staphylococcus epidermidis (MRSE) isolates.

Methods: A comprehensive search was conducted through data medical data bases using a combination of mesh terms. The data were analyzed using STATA meta-analysis software, and a random effects model was employed to determine the pooled prevalence with a 95% confidence interval (CI).

Results: Our findings revealed that the prevalence of MRSA was 61.75% (95% CI: 35.6-99.1). The cumulative rate of biofilm formation in MRSE strains was reported to be 83.4% (95% CI: 47.8-99.4). Among the biofilm-related genes, the SdrG gene exhibited the highest frequency (98%), followed by the atlG gene with a frequency of 84%.

Conclusion: Out of the seven, three documented a positive association. Given the propensity of MRSE strains to form biofilms, it is crucial to implement preventive measures against infections caused by these strains.

Keywords: Biofilm formation; Methicillin-resistant Staphylococcus epidermidis.

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Conflict of interest statement

Authors declare that they have no conflict of interest.

Figures

Figure 2
Figure 2
Flow charts for the studies were identified, displayed, and included in the study
Figure 3
Figure 3
Forest plot of the prevalence of MRSE isolates
Figure 4
Figure 4
Funnel plot of the MRSE isolates
See this image and copyright information in PMC

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