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Case Reports
. 2025 Aug;18(3):189-200.
doi: 10.1177/18758894251347128. Epub 2025 Jun 27.

Safety of cardiorespiratory and muscle fitness assessment in two children with leukemia during early chemotherapy

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Case Reports

Safety of cardiorespiratory and muscle fitness assessment in two children with leukemia during early chemotherapy

Virginie Aspirot-Buron et al. J Pediatr Rehabil Med. 2025 Aug.

Abstract

PurposeLimited data are available on the cardiorespiratory and muscle fitness of children with acute lymphoblastic leukemia (ALL) during chemotherapy. This pilot study evaluated the safety of testing the cardiorespiratory and muscle fitness of two children with ALL at different risk levels in early chem treatment.MethodsTwo girls with low- and high-risk B-cell ALL (DFCI-16-001) took part in two test sessions: T1 (induction, consolidation 1A/C) and T2 (consolidation 2). Each testing session included a maximal oxygen uptake (V˙O2max) exercise test, muscular strength tests, physical activity and quality of life questionnaires, and a semi-structured interview. The parents agreed to these assessments at the start of chemotherapy treatment.ResultsThe participants experienced no significant adverse effects from undertaking the cardiorespiratory and muscular tests, and there was no impact on their chemotherapy treatment schedule. At their post-test interview, both participants reported that thigh pain and fatigue were the most difficult part of the V˙O2max exercise test. Regarding physical performance outcomes, both participants exhibited low scores compared to their gender, weight- and age-predicted V˙O2max and on most strength test values.ConclusionThe physical tests were safely and successfully conducted with these two participants during early chemotherapy.

Keywords: cardiorespiratory; childhood cancer; hematologic cancer; physical activity; physical status.

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