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. 2025 Jun 5;63(6):myaf054.
doi: 10.1093/mmy/myaf054.

Genome characterization of Trichophyton mentagrophytes genotype VII strain PG12DES from Italy

Luca Rossi  1 , Annarita Sorrentino  2 , Prof Caterina Signoretto  1   2 , Paolo Gaibani  1   2
Affiliations

Genome characterization of Trichophyton mentagrophytes genotype VII strain PG12DES from Italy

Luca Rossi et al. Med Mycol. .

Abstract

We characterized the genome of the clinical Trichophyton mentagrophytes genotype VII strain PG12DES. PG12DES genome harbored different virulence factors, including MEP-1, MEP-2, MEP-3, MEP-4, SUB-6, and ZAF-A. Phylogenetic analysis revealed that PG12DES was clonally related to a T. mentagrophytes strain isolated in Moldova in 2017. This study provides the genome characterization of a clinical strain from Italy and broadens the knowledge of the emergent genotype VII.

Keywords: SQLE gene; Trichophyton mentagrophytes; dermatophytes; genotype VII; terbinafine-resistance; whole-genome sequencing (WGS).

Plain language summary

In past years, the emergence of Trichophyton mentagrophytes type VII (TMVII) has been reported worldwide. Here, we characterized the genome of a clinical strain from Italy and compared that to genomes from other globally collected strains.

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Conflict of interest statement

None declared.

Figures

Figure 1.
Figure 1.
Phylogenetic analysis based on the core genome SNPs of the T. mentagrophytes genomes. SNP density plot among T. mentagrophytes genomes is shown in the right part of the figure. The PG12DES strain object of this study is highlighted in blue. The scale bar represents substitutions per site.
See this image and copyright information in PMC

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