Sequential assessment of septic patients for immune profiling: A focus on persistent inflammation, immunosuppression, and catabolism syndrome

Burcin Halacli¹, Kevser Yilmaz², Rabia Kara², Aslihan Berra Bolat³, Arzu Topeli⁴, Ilhan Tezcan⁵, Sevil Oskay Halacli⁶, Deniz Cagdas⁷

Affiliations

¹ Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, 06100 Ankara, Türkiye; Hacettepe University Sepsis Research and Education Center, 06100 Ankara, Türkiye. Electronic address: burcin.halacli@yahoo.com.
² Hacettepe University, Institute of Childs' Health, Department of Basic Sciences of Pediatrics, 06100 Ankara, Türkiye.
³ Hacettepe University, Faculty of Medicine, 06100 Ankara, Türkiye.
⁴ Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, 06100 Ankara, Türkiye; Hacettepe University Sepsis Research and Education Center, 06100 Ankara, Türkiye.
⁵ Hacettepe University, Faculty of Medicine, Department of Childs' Health and Disease, Division of Pediatric Immunology, 06100 Ankara, Türkiye.
⁶ Hacettepe University Sepsis Research and Education Center, 06100 Ankara, Türkiye; Hacettepe University, Institute of Childs' Health, Department of Basic Sciences of Pediatrics, 06100 Ankara, Türkiye; Hacettepe University, Faculty of Medicine, Department of Childs' Health and Disease, Division of Pediatric Immunology, 06100 Ankara, Türkiye; Hacettepe University, Faculty of Medicine, Translational Medicine Laboratories, 06100 Ankara, Türkiye.
⁷ Hacettepe University, Institute of Childs' Health, Department of Basic Sciences of Pediatrics, 06100 Ankara, Türkiye; Hacettepe University, Faculty of Medicine, Department of Childs' Health and Disease, Division of Pediatric Immunology, 06100 Ankara, Türkiye.

PMID: 40578261
DOI: 10.1016/j.jcrc.2025.155158

Sequential assessment of septic patients for immune profiling: A focus on persistent inflammation, immunosuppression, and catabolism syndrome

Burcin Halacli et al. J Crit Care. 2025 Oct.

. 2025 Oct:89:155158.

doi: 10.1016/j.jcrc.2025.155158. Epub 2025 Jun 26.

Authors

Burcin Halacli¹, Kevser Yilmaz², Rabia Kara², Aslihan Berra Bolat³, Arzu Topeli⁴, Ilhan Tezcan⁵, Sevil Oskay Halacli⁶, Deniz Cagdas⁷

Affiliations

¹ Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, 06100 Ankara, Türkiye; Hacettepe University Sepsis Research and Education Center, 06100 Ankara, Türkiye. Electronic address: burcin.halacli@yahoo.com.
² Hacettepe University, Institute of Childs' Health, Department of Basic Sciences of Pediatrics, 06100 Ankara, Türkiye.
³ Hacettepe University, Faculty of Medicine, 06100 Ankara, Türkiye.
⁴ Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Intensive Care Medicine, 06100 Ankara, Türkiye; Hacettepe University Sepsis Research and Education Center, 06100 Ankara, Türkiye.
⁵ Hacettepe University, Faculty of Medicine, Department of Childs' Health and Disease, Division of Pediatric Immunology, 06100 Ankara, Türkiye.
⁶ Hacettepe University Sepsis Research and Education Center, 06100 Ankara, Türkiye; Hacettepe University, Institute of Childs' Health, Department of Basic Sciences of Pediatrics, 06100 Ankara, Türkiye; Hacettepe University, Faculty of Medicine, Department of Childs' Health and Disease, Division of Pediatric Immunology, 06100 Ankara, Türkiye; Hacettepe University, Faculty of Medicine, Translational Medicine Laboratories, 06100 Ankara, Türkiye.
⁷ Hacettepe University, Institute of Childs' Health, Department of Basic Sciences of Pediatrics, 06100 Ankara, Türkiye; Hacettepe University, Faculty of Medicine, Department of Childs' Health and Disease, Division of Pediatric Immunology, 06100 Ankara, Türkiye.

PMID: 40578261
DOI: 10.1016/j.jcrc.2025.155158

No abstract available

Keywords: Chronic critical illness; Immune dysregulation; Immune resolution; Immunology; Sepsis.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflict of interest.

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Sequential assessment of septic patients for immune profiling: A focus on persistent inflammation, immunosuppression, and catabolism syndrome

Affiliations

Sequential assessment of septic patients for immune profiling: A focus on persistent inflammation, immunosuppression, and catabolism syndrome

Authors

Affiliations

Conflict of interest statement

Publication types

LinkOut - more resources

Full Text Sources