Cannabinoids as Potential Therapeutic Agents in the Treatment of Pancreatic Cancer

Abstract

Pancreatic cancer is one of the most aggressive and lethal malignancies, with limited therapeutic options and low survival rates, primarily due to late-stage diagnosis and resistance to conventional therapies. Recently, cannabinoids have gained attention for their analgesic and antiemetic properties in cancer symptom management, as well as for their potential anticancer effects. This review explores the mechanisms by which cannabinoids may impact pancreatic cancer progression, focusing on their molecular interactions and therapeutic potential.

Keywords: Pancreatic cancer; THC; anti-cancer effects; apoptosis; cannabidiol; cannabinoids; clinical trials; endocannabinoid system.