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. 2025 Jul-Aug;39(4):2144-2153.
doi: 10.21873/invivo.14010.

The Effect of Preoperative Dry Eye Disease on the Outcome of Second (Visumax 800) Generation Keratorefractive Lenticule Extraction Surgery

Chia-Yi Lee #  1   2   3 , Shun-Fa Yang #  1   4 , Ie-Bin Lian  5 , Hung-Chi Chen  6   7   8 , Jing-Yang Huang  4 , Chao-Kai Chang  9   10
Affiliations

The Effect of Preoperative Dry Eye Disease on the Outcome of Second (Visumax 800) Generation Keratorefractive Lenticule Extraction Surgery

Chia-Yi Lee et al. In Vivo. 2025 Jul-Aug.

Abstract

Background/aim: To evaluate the influence of preoperative dry eye disease (DED) on the postoperative outcome of second generation keratorefractive lenticule extraction (KLEx) surgery.

Patients and methods: A retrospective cohort study was performed and patients who received second generation KLEx surgery were enrolled. After the categorization, a total of 76, 59, and 65 eyes were put into the non-DED, DED without artificial tear (AT), and DED with AT groups, respectively. The primary outcomes were the uncorrected distance visual acuity (UDVA), spherical equivalent (SE), and postoperative complications. The one-way ANOVA was applied for the statistical analysis.

Results: One day postoperatively, the DED without AT group demonstrated a significantly worse UDVA compared to the other two groups (p=0.002). At the final visit, the UDVA in this group was not significantly lower from that in the non-DED and DED with AT groups (p=0.129). The SE was significantly higher in the DED without AT group than the other two groups from postoperatively day one through three months (all p<0.05). Moreover, the change in UDVA over time was significantly greater in the DED without AT group than in the other two groups (p=0.007). Regarding the vector analysis, the difference vector (DV), correction index (CoI), and angle of error (AE) was significantly higher in the DED without AT group compared to the other two groups (all p<0.05). The rate of postoperative superficial keratitis and DED was significantly higher in the DED without AT group compared to the other two groups (both p<0.05).

Conclusion: The presence of preoperative DED is associated with worse postoperative UDVA recovery and refraction of second generation KLEx surgery, which can be prevented by preoperative AT application.

Keywords: Keratorefractive lenticule extraction; dry eye disease; spherical equivalent; uncorrected distance visual acuity; visumax 800.

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Conflict of interest statement

The Authors have no proprietary or commercial interest in any materials mentioned in this article.

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