Addendum: Unravelling cysteine-deficiency-associated rapid weight loss

Alan Varghese^#^{1

2}, Ivan Gusarov^#², Begoña Gamallo-Lana³, Daria Dolgonos¹, Yatin Mankan¹, Ilya Shamovsky², Mydia Phan¹, Rebecca Jones⁴, Maria Gomez-Jenkins^{5

6}, Eileen White^{5

6

7}, Rui Wang⁸, Drew R Jones², Thales Papagiannakopoulos⁹, Michael E Pacold¹⁰, Adam C Mar³, Dan R Littman^{11

12}, Evgeny Nudler^{13

14}

Affiliations

¹ Department of Cell Biology, NYU Grossman School of Medicine, New York, NY, USA.
² Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.
³ Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA.
⁴ Division of Advanced Research Technologies, NYU Grossman School of Medicine, New York, NY, USA.
⁵ Rutgers Cancer Institute, Rutgers University, New Brunswick, NJ, USA.
⁶ Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA.
⁷ Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.
⁸ Department of Biology, York University, Toronto, Ontario, Canada.
⁹ Department of Pathology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
¹⁰ Department of Radiation Oncology and Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
¹¹ Department of Cell Biology, NYU Grossman School of Medicine, New York, NY, USA. Dan.Littman@med.nyu.edu.
¹² Howard Hughes Medical Institute, New York, NY, USA. Dan.Littman@med.nyu.edu.
¹³ Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA. Evgeny.Nudler@nyulangone.org.
¹⁴ Howard Hughes Medical Institute, New York, NY, USA. Evgeny.Nudler@nyulangone.org.

^# Contributed equally.

Alan Varghese et al. Nature. 2025 Jul.

. 2025 Jul;643(8072):E16.

doi: 10.1038/s41586-025-09282-7.

¹ Department of Cell Biology, NYU Grossman School of Medicine, New York, NY, USA.
² Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.
³ Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA.
⁴ Division of Advanced Research Technologies, NYU Grossman School of Medicine, New York, NY, USA.
⁵ Rutgers Cancer Institute, Rutgers University, New Brunswick, NJ, USA.
⁶ Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA.
⁷ Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.
⁸ Department of Biology, York University, Toronto, Ontario, Canada.
⁹ Department of Pathology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
¹⁰ Department of Radiation Oncology and Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
¹¹ Department of Cell Biology, NYU Grossman School of Medicine, New York, NY, USA. Dan.Littman@med.nyu.edu.
¹² Howard Hughes Medical Institute, New York, NY, USA. Dan.Littman@med.nyu.edu.
¹³ Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA. Evgeny.Nudler@nyulangone.org.
¹⁴ Howard Hughes Medical Institute, New York, NY, USA. Evgeny.Nudler@nyulangone.org.