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Meta-Analysis
. 2025 Aug;194(4):1391-1400.
doi: 10.1007/s11845-025-03985-6. Epub 2025 Jun 28.

The effect of psychotherapeutic interventions on pain and quality of life in endometriosis: a systematic review and meta-analysis study

Handan Özcan  1 , Ayşe Çuvadar  2 , Sevda Uzun  3
Affiliations
Meta-Analysis

The effect of psychotherapeutic interventions on pain and quality of life in endometriosis: a systematic review and meta-analysis study

Handan Özcan et al. Ir J Med Sci. 2025 Aug.

Abstract

Aim: This study aimed to determine the effect of psychotherapeutic interventions on pain, quality of life and health profile in women diagnosed with endometriosis.

Methods: For this systematic review and meta-analysis study, studies were obtained by searching PubMed, Web of Science, EBSCOhost, Google Scholar, and YÖK Thesis Center databases between August and October 2024 without any year limitation. After the review, 10 studies were included in the study. The data were synthesized by meta-analysis and narrative methods.

Results: In this systematic review and meta-analysis, psychotherapeutic interventions for the treatment and management of endometriosis were found to be effective on quality of life (SMD = 0.515, 95% CI = 0.035 to 0.995; Z = 2.104, I2 = 67.523%, p < 0.05), pain (SMD = - 0.454, 95% CI = - 1.600 to - 0.179; Z = - 1.566, I2 = 84.463, p > 0.05), and health profile (SMD = 0.041, 95% CI = - 0.363 to 0.281; Z = - 0.250759, I2 = 56.876%, p > 0.05). In subgroup analyses, it was determined that the types of psychotherapeutic interventions were not effective, but the number of sessions was effective.

Conclusion: Psychotherapeutic interventions to reduce symptoms in endometriosis are effective in improving quality of life but not pain and health profile.

Keywords: Endometriosis; Pain; Psychotherapeutic intervention; Quality of life.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Selection of studies according to PRISMA flow diagram
Fig. 2
Fig. 2
Funnel plot of studies reporting results on the effect of psychotherapeutic interventions on quality of life in endometriosis
Fig. 3
Fig. 3
Forest plot for the effect of psychotherapeutic interventions on quality of life in endometriosis
Fig. 4
Fig. 4
Funnel plot of studies reporting results on the effect of psychotherapeutic interventions on pain in endometriosis
Fig. 5
Fig. 5
Forest plot for the effect of psychotherapeutic interventions on pain in endometriosis
Fig. 6
Fig. 6
Funnel plot of studies reporting results on the effect of psychotherapeutic interventions on health profile in endometriosis
Fig. 7
Fig. 7
Forest plot for the effect of psychotherapeutic interventions on health profile in endometriosis
See this image and copyright information in PMC

References

    1. Xu Y, Zhao W, Li T, Zhao Y, Bu H, Song S (2017) Effects of acupuncture for the treatment of endometriosis-related pain: a systematic review and meta-analysis. PLoS ONE 12(10):e0186616 - DOI - PMC - PubMed
    1. Yan Q, Li J, Zeng J (2021) The role of acupuncture in the treatment of women with pain in endometriosis. Medicine 100(49):1–2 - DOI - PMC - PubMed
    1. Oszajca K, Adamus A (2024) Diet in prevention and treatment of endometriosis: current state of knowledge. Curr Nutr Rep 13:49–58 - DOI - PubMed
    1. Kim JH, Han E (2018) Endometriosis and female pelvic pain. Semin Reprod Med 36:14–151 - PubMed
    1. Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S et al (2019) Endometriosis. Endocr Rev 40:1048–1079 - DOI - PMC - PubMed

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