Targeting the double-edged sword: cytokines in the pathogenesis and treatment of autoimmune diseases

Abstract

Autoimmune diseases are often idiopathic, with complex immune cell interactions that remain poorly understood. Cytokines, signaling molecules with a dual nature, play a pivotal role in these conditions. While they are essential for regulating immune responses and have therapeutic applications, they can also contribute to inflammation and the development of autoimmune disorders. Key cytokines such as tumor necrosis factor -α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-17 (IL-17), interleukin-23 (IL-23), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interferon-gamma (IFN-γ) have been implicated in the pathogenesis of autoimmune diseases like inflammatory bowel disease (IBD), multiple sclerosis (MS), and rheumatoid arthritis (RA). This review aims to explore the dual role of cytokines in autoimmune diseases, focusing on their involvement in disease pathogenesis and their potential as therapeutic targets. It evaluates the mechanisms and clinical outcomes of anti-cytokine inhibitors while highlighting gaps in current research that could pave the way for improved treatments. Anti-cytokine therapies have shown significant promise in managing conditions like IBD, MS, and RA, but challenges remain in optimizing their efficacy and minimizing side effects. Further research is needed to better understand the intricate roles of cytokines in autoimmunity and to refine therapeutic strategies, ultimately improving patient outcomes.

Keywords: Anti-cytokine therapies; Autoimmune diseases; Cytokines; Inflammation.