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. 2025 Oct 17;193(5):1004-1007.
doi: 10.1093/bjd/ljaf257.

Comprehensive profiling of the mutational landscape of hidradenoma papilliferum validates key role of alterations in the phosphoinositide 3-kinase/AKT pathway

Saamin Cheema  1 , Louise van der Weyden  1 , Kim Wong  1 , Martin Del Castillo Velasco-Herrera  1 , Jamie Billington  1 , Ian Vermes  1 , Elizabeth Anderson  1 , Laura Allen  1 , Nicolas de Saint Aubain, Michiel P J van der Horst, Ahmed K Alomari, Carolin Mogler, Carlos Monteagudo, Derek Frew, Steven D Billings, Mark J Arends, Ingrid Ferreira  1 , Thomas Brenn, David J Adams  1
Affiliations

Comprehensive profiling of the mutational landscape of hidradenoma papilliferum validates key role of alterations in the phosphoinositide 3-kinase/AKT pathway

Saamin Cheema et al. Br J Dermatol. .

Abstract

Comprehensive characterization of the mutational landscape of hidradenoma papilliferum (HP) identified PIK3CA and PIK3R1 as mutually exclusive driver genes. Taken together with the mutation of other genes involved in phosphoinositide 3-kinase/AKT signalling, our findings confirm a key role of the alteration of this pathway in the pathogenesis of HP. The absence of a significant presence of human papillomavirus (HPV) sequences suggests that HPV is not involved in the aetiology of HP.

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Conflict of interest statement

Conflicts of interest: The authors have no competing or financial interests to declare.

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