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. 2025 Aug 25;64(35):e202506054.
doi: 10.1002/anie.202506054. Epub 2025 Jul 14.

Homologous Ladder Cyclohexasilanes

Fan Fang  1 , Andrew Molino  2 , Kelsie E Wentz  1 , Carlton P Folster  1 , Jessica L Williams  1 , Maxime A Siegler  1 , Rebekka S Klausen  1
Affiliations

Homologous Ladder Cyclohexasilanes

Fan Fang et al. Angew Chem Int Ed Engl. .

Abstract

We report the synthesis of five new examples of ladder cyclohexasilanes, possessing up to three consecutive fused rings and differing in relative ring fusion configuration and side chain structure. By coupling a 1,4-dipotassiooligosilyl dianion to a cyclohexasilane, we obtained bi- and tricyclic ladder cyclohexasilanes. Combined experimental and theoretical studies suggested that annulation could favor the cis configuration under kinetic control, while the trans configuration predominates under thermodynamic control. Computational studies show that with each additional ring in the trans-diastereomeric series, the predicted onset of light absorption shifts to longer wavelengths.

Keywords: Annulation; Conjugation; Diastereoselectivity; Ladder polymers; Silanes.

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