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. 2025 Jun 27;17(6):103336.
doi: 10.4240/wjgs.v17.i6.103336.

Endoscopic anti-reflux mucosal resection for patients with gastroesophageal reflux disease: Clinical efficacy and impact on gut microbiota

Zhe Han  1 , Hai-Bo Jiang  1 , Fan-Ke Wang  1 , Zhong-Yu Wang  1 , Hong-Fei Pang  1 , Yuan-Yuan Wang  2 , Ming Wei  1
Affiliations

Endoscopic anti-reflux mucosal resection for patients with gastroesophageal reflux disease: Clinical efficacy and impact on gut microbiota

Zhe Han et al. World J Gastrointest Surg. .

Abstract

Background: In recent years, endoscopic anti-reflux mucosal resection (ARMS) has demonstrated benefits, including good efficacy, ease of operation, low cost, and fewer complications; however, it is still in the exploratory stage.

Aim: To evaluate the clinical efficacy of ARMS in patients with gastroesophageal reflux disease (GERD) and its effects on the gut microbiota.

Methods: This single-center, retrospective, self-controlled study included 80 patients with GERD. All patients underwent endoscopic ARMS and were followed for at least 3 months after surgery. The primary outcome measures were changes in the gut microbiota before and after treatment and clinical efficacy.

Results: After surgery, the counts of Escherichia coli and Staphylococcus aureus were significantly lower than those before surgery (P < 0.05), whereas the counts of Bifidobacterium and Lactobacillus were significantly higher than those before surgery (P < 0.05). Symptoms, such as reflux and heartburn, were markedly relieved postoperatively. The average Gerd Q score prior to surgery was 11.32 ± 1.26 points, which decreased to 5.89 ± 0.52 points 3 months after surgery. All patients used proton pump inhibitors before surgery, and the proportion of patients using proton pump inhibitors declined significantly postoperatively. Sixteen patients (20.0%) experienced surgery-related adverse reactions within 2 weeks to 1 month post-surgery. The incidence rates of postoperative esophageal stricture and delayed bleeding were 15.0% and 5.0%, respectively.

Conclusion: Endoscopic ARMS can effectively alleviate reflux symptoms, maintain gut microbiota balance, and improve gastrointestinal function in patients with GERD.

Keywords: Anti-reflux therapy; Endoscopic anti-reflux mucosal resection; Gastroesophageal reflux disease; Gastrointestinal function; Gut microbiota.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.

Figures

Figure 1
Figure 1
Comparison of proton pump inhibitor medication rates and reduction rates before and three months after surgery. A: Comparison of proton pump inhibitor medication rates; B: Comparison of proton pump inhibitor reduction rate. aP < 0.01. PPI: Proton pump inhibitor.
See this image and copyright information in PMC

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