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. 2025 Jul;24(7):e70321.
doi: 10.1111/jocd.70321.

Effectiveness of an Autologous Micrografting Technology for Treating Stretch Marks

Andrea Garelli  1 , Valeria Pessei  2   3 , Ruggero Tagliabue  4 , Olha Sles  5 , Ratchathorn Panchaprateep  6   7
Affiliations

Effectiveness of an Autologous Micrografting Technology for Treating Stretch Marks

Andrea Garelli et al. J Cosmet Dermatol. 2025 Jul.

Abstract

Background: Stretch marks or striae distensae (SD) are common dermal lesions caused by the disruption of collagen and elastin fibers in the skin, often triggered by rapid mechanical stretching. Despite the availability of numerous treatment modalities, from topical agents to energy-based devices, no single therapy has demonstrated consistent, long-term efficacy across all patient populations. The pathophysiology of SD involves complex alterations in the extracellular matrix (ECM), particularly affecting fibroblast activity and collagen/elastin synthesis.

Aims: This pilot study aims to evaluate the clinical and molecular efficacy of autologous micrografting technology as a novel therapeutic option for SD. Specifically, it investigates the treatment's impact on ECM-related gene expression and overall skin appearance.

Patients/methods: Fourteen patients (13 females, 1 male) with clinically evident SD were enrolled. All participants underwent a standardized treatment protocol comprising microneedling followed by intradermal injection of autologous micrografts, obtained via a minimally invasive procedure. Clinical assessments were performed through standardized photography at baseline, 1 month, and 6 months post-treatment. In vitro assays were conducted on cultured human dermal fibroblasts exposed to the micrograft suspension.

Results: Clinical evaluations showed noticeable aesthetic improvements, including reduced striae visibility and improved skin texture, with high patient-reported satisfaction. Molecular analyses revealed the upregulation of key ECM genes, including COL4A1, COL6A1, and ELN, indicating enhanced fibroblast activation and regenerative potential.

Conclusions: Autologous micrografting appears to be a promising, biologically active approach for SD treatment. It promotes ECM remodeling by stimulating fibroblast function and may represent a valuable addition to the therapeutic landscape for stretch marks.

Keywords: autologous micrografts; collagen; elastin; gene expression; stretch marks.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Clinical appearance of the gluteal region showing stretch marks and pre‐procedural markings. The green marks indicate reference points for the planned procedure.
FIGURE 2
FIGURE 2
Visual comparison of stretch marks before treatment (A). 1 month after treatment (B), and 6 months after treatment (C). The images illustrate changes in skin appearance following the procedure.
FIGURE 3
FIGURE 3
Visual comparison of stretch marks before treatment (A), 1 month after treatment (B), and 6 months after treatment (C). The images illustrate changes in skin appearance following the procedure.
FIGURE 4
FIGURE 4
Evaluation of skin texture before treatment (A), 1 month after treatment (B), and 6 months after treatment (C). The images highlight changes in surface smoothness and structural appearance over time.
FIGURE 5
FIGURE 5
Gene expression results obtained by RT‐PCR in fibroblasts cultured with standard medium (control) or micrograft suspension for 24 and 48 h. Gene expression of (A) Collagen 4 (COL4A1), (B) Elastin (ELN), and (C) Collagen 6 (COL6A1). The data show the effects of micrograft suspension on the expression of key extracellular matrix components over time compared to the control group.
See this image and copyright information in PMC

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