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Review
. 2025 Jan-Dec:32:10732748251353077.
doi: 10.1177/10732748251353077. Epub 2025 Jun 30.

The Biological Role of LRPPRC in Human Cancers

Jiaxin Tang  1   2 , Jing Li  1   2 , Shiyu Qin  1   2 , Yu Xiao  1   2 , Jiaxin Liu  1   2 , Xian Chen  1   2 , Yunyuan Zhang  1   2
Affiliations
Review

The Biological Role of LRPPRC in Human Cancers

Jiaxin Tang et al. Cancer Control. 2025 Jan-Dec.

Abstract

The leucine-rich pentatricopeptide repeat-containing (LRPPRC) protein, a member of the pentatricopeptide repeat (PPR) family, is a mitochondria-associated protein that regulates various biological processes, including cell cycle progression and mitochondrial gene translation. LRPPRC has also been identified as an important causative gene in several mitochondrial diseases. N6-methyladenosine (m6A) is the most prevalent and extensive modification of mRNA in eukaryotes, playing a significant role in cellular proliferation, differentiation, and oncogenesis. As an m6A regulator, LRPPRC has been shown to play an important role in the development of various human metabolic diseases and malignant tumors. This review mainly focuses on summarizing the biological roles of LRPPRC in a variety of human malignant tumors, emphasizing the molecular mechanisms LRPPRC is involved in and its potential impact on tumor prognosis.

Keywords: LRPPRC; cancer, biological roles; m6A.

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Conflict of interest statement

Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Expression of LRPPRC Across Various Cancer Types
Figure 2.
Figure 2.
The Role of LRPPRC in Regulating Multiple Human Cancers and Many Signal Pathways
Figure 3.
Figure 3.
The Role of LRPPRC in Regulating Multiple Human Cancers in Radar Chart
See this image and copyright information in PMC

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