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Comment
. 2025 Jul 8;122(27):e2511399122.
doi: 10.1073/pnas.2511399122. Epub 2025 Jun 30.

15-PGDH inhibition preserves blood-brain barrier integrity and cognition

Daisy M van Egmond #  1   2   3   4 , Anita Lygeroudi #  1   2   4 , Gijs Kooij  1   2   3   4
Affiliations
Comment

15-PGDH inhibition preserves blood-brain barrier integrity and cognition

Daisy M van Egmond et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Competing interests statement:The authors declare no competing interest.

Comment on

  • Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury.
    Koh Y, Vázquez-Rosa E, Gao F, Li H, Chakraborty S, Tripathi SJ, Barker S, Bud Z, Bangalore A, Kandjoze UP, León-Alvarado RA, Sridharan PS, Cordova BA, Yu Y, Hyung J, Fang H, Singh S, Katabathula R, LaFramboise T, Kasturi L, Lutterbaugh J, Beard L, Cordova E, Cintrón-Pérez CJ, Franke K, Fragoso MF, Miller E, Indrakumar V, Noel KL, Dhar M, Ajroud K, Zamudio C, Lopes FBTP, Bambakidis E, Zhu X, Wilson B, Flanagan ME, Gefen T, Fujioka H, Fink SP, Desai AB, Dawson D, Williams NS, Kim YK, Ready JM, Paul BD, Shin MK, Markowitz SD, Pieper AA. Koh Y, et al. Proc Natl Acad Sci U S A. 2025 May 27;122(21):e2417224122. doi: 10.1073/pnas.2417224122. Epub 2025 May 21. Proc Natl Acad Sci U S A. 2025. PMID: 40397680 Free PMC article.

References

    1. Sweeney M. D., Sagare A. P., Zlokovic B. V., Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat. Rev. Neurol. 14, 133–150 (2018). - PMC - PubMed
    1. Koh Y., et al. , Inhibiting 15-PGDH blocks blood–brain barrier deterioration and protects mice from Alzheimer’s disease and traumatic brain injury. Proc. Natl. Acad. Sci. U.S.A. 122, e2417224122 (2025). - PMC - PubMed
    1. Zhang Y., et al. , Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science 348, aaa2340 (2015). - PMC - PubMed
    1. Palla A. R., et al. , Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength. Science 371, eabc8059 (2021). - PMC - PubMed
    1. Sun C.-C., et al. , Recent advances in studies of 15-PGDH as a key enzyme for the degradation of prostaglandins. Int. Immunopharmacol. 101, 108176 (2021). - PubMed

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