Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Oct;68(10):2088-2091.
doi: 10.1007/s00125-025-06484-6.

Raising the bar for publication of Mendelian randomisation studies in Diabetologia

Laura J Corbin  1   2 , Jordi Merino  3 , Tove Fall  4   5 , Christian Herder  6   7   8
Affiliations
Editorial

Raising the bar for publication of Mendelian randomisation studies in Diabetologia

Laura J Corbin et al. Diabetologia. 2025 Oct.
No abstract available

Keywords: Guidance; Mendelian randomisation; Quality; Reproducibility; Triangulation.

PubMed Disclaimer

Conflict of interest statement

Acknowledgements: The authors would like to thank G. Hemani, G. Davey Smith and N. J. Timpson (University of Bristol) and M. J. Redondo (Baylor College of Medicine) for their helpful comments during the preparation of this manuscript. Funding: LJC is based at the Medical Research Council funded MRC Integrative Epidemiology Unit (MC_UU_00032/1). CH is based at The German Diabetes Center which is funded by the German Federal Ministry of Health (Berlin, Germany) and the Ministry of Culture and Science of the state North Rhine-Westphalia (Düsseldorf, Germany) and receives additional funding from the German Federal Ministry of Education and Research (BMBF) through the German Center for Diabetes Research (DZD e.V.). Work in JM’s laboratory is supported by the Novo Nordisk Foundation grant NNF23SA0084103, the EFSD/Novo Nordisk Foundation Future Leaders Award (no. 0094134) and the European Union (HORIZON-EIC-2023-PATHFINDERCHALLENGES-01-101161509). Views and opinions expressed are, however, those of the authors only and do not necessarily reflect those of the European Union or European Innovation Council and SMEs Executive Agency (EISMEA). Neither the European Union nor the granting authority can be held responsible for them. TF’s research group has financial support from the European Research Council (ERC-2018-STG801965), the Swedish Research Council (VR 2019-01471) and the Swedish Heart-Lung Foundation (Hjärt-Lungfonden, 2023-0687 and Göran Gustafsson Foundation KVA [2025]). Authors’ relationships and activities: Authors are all members of the Diabetologia Editorial Board. Contribution statement: LJC produced the first draft of the article. All authors were responsible for reviewing it critically for important intellectual content and editing it accordingly. All authors approved the version to be published.

References

    1. Bours MJL (2020) A nontechnical explanation of the counterfactual definition of confounding. J Clin Epidemiol 121:91–100. https://doi.org/10.1016/j.jclinepi.2020.01.021 - DOI - PubMed
    1. Imbens GW, Wooldridge JM (2009) Recent developments in the econometrics of program evaluation. J Econ Lit 47(1):5–86. https://doi.org/10.1257/JEL.47.1.5 - DOI
    1. Widding-Havneraas T, Zachrisson HD (2022) A gentle introduction to instrumental variables. J Clin Epidemiol 149:203–205. https://doi.org/10.1016/j.jclinepi.2022.06.022 - DOI - PubMed
    1. Davey Smith G, Ebrahim S (2003) ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32(1):1–22. https://doi.org/10.1093/ije/dyg070 - DOI
    1. Archimbaud E, Thomas X, Michallet M et al (1994) Prospective genetically randomized comparison between intensive postinduction chemotherapy and bone marrow transplantation in adults with newly diagnosed acute myeloid leukemia. J Clin Oncol 12(2):262–267. https://doi.org/10.1200/JCO.1994.12.2.262 - DOI - PubMed

Publication types

LinkOut - more resources