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. 2025 Jun 30.
doi: 10.1111/jsap.13910. Online ahead of print.

Understanding the rationale for metronidazole use in dogs and cats

J Ng  1   2 , N Steffensen  3 , I Battersby  4 , J S Weese  5 , D Timofte  6 , P L Toutain  7 , J L Granick  8 , J Elliott  7 , S Choi  2 , T Sparks  9 , S Tavener  10 , F Allerton  2
Affiliations

Understanding the rationale for metronidazole use in dogs and cats

J Ng et al. J Small Anim Pract. .

Abstract

Objective: It is currently unknown how often antibiotics (including metronidazole) are used for non-antibacterial purposes in dogs and cats. This study looked to characterise the rationale for metronidazole prescription in these species.

Methods: Retrospective cohort study. Veterinarians reported clinical information for dogs and cats treated with metronidazole in the previous year, including the rationale for metronidazole selection.

Results: Three hundred and thirty-two cases were reported by 138 veterinarians describing metronidazole use in 47 cats and 285 dogs. Metronidazole was most commonly prescribed to treat acute diarrhoea (n = 156, 47%), chronic diarrhoea (n = 79, 24%) or giardiasis (n = 36, 11%). Veterinarians selected metronidazole exclusively for non-antimicrobial targeted therapy in 42% of cases (125/300). Putative anti-inflammatory/immunomodulatory properties were cited in 64% of cases (213/332). Educational resources (41/92, 45%), team-based collaboration (29/92, 32%) and specialist consultation (10/92, 11%) were cited as the supportive basis for these prescription choices.

Clinical significance: Veterinarians are using metronidazole frequently for non-antimicrobial properties in contradiction to antimicrobial use guidelines. Future stewardship programs should adapt guidance specifically to counter this prescribing behaviour.

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