Nano Fat Therapy and Platelet Rich Plasma Versus Nano Fat Therapy Alone on Burn Scar

Abstract

The aim of the study was to identify the efficacy of platelet rich plasma plus nano fat therapy in comparison to nano fat therapy alone on burn scars. The study was conducted at the Department of Plastic & Reconstructive Surgery Dr. Ruth KM Pfau, Civil Hospital Karachi, Dow University of Health Sciences Pakistan from March 2021 to February 2022. Sixty-four patients with mature burn scar of both genders aged eighteen and above were included and randomly distributed in 2 groups: one group received treatment with nano fat therapy whereas the other group received treatment with nano fat therapy and platelet rich plasma. Vancouver scar scale (VSS) score was used to assess the scar at baseline, 1 month, 3 months and finally after 6 months. For both groups, the highest mean total VSS score values were observed at baseline and lowest at 6 months. All mean values at various points for the PRP + nano fat group were lower than mean values for the nano fat group. However, the mean difference between the two groups for scores after 6 months was insignificant. It was concluded that results of both treatments are equivocal.

Keywords: applications; burns; efficacy; healing; nano fat therapy; platelet-rich plasma; regeneration; surgery; wound healing.

Fig. 1

(Nano fat case) A 20-year-old female patient with a fire burn scar 4x3 cm. A) Initial presentation of the participant at baseline; B) At first follow up after one month; C) At second follow up after 3 months, shows progress in the status of scar; D) At the final follow up after 6 months, the wound has improved.

Fig. 2

(Nano fat + PRP case). A 19-year-old female patient with an acid burn scar of approximately 3x4 cm. A) Presentation of the patient at baseline; B) At first follow up after one month; C) At second follow up after 3 months; D) At the final follow up after 6 months, the wound has significantly improved.