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. 2025 Jul 1:19476035251351781.
doi: 10.1177/19476035251351781. Online ahead of print.

Direct Fixation of Acute Chondral-Only Fragments in Young Patients

Affiliations

Direct Fixation of Acute Chondral-Only Fragments in Young Patients

Paul B Walker et al. Cartilage. .

Abstract

IntroductionCartilage lesions of the knee frequently result from acute traumatic injuries and pose significant challenges, particularly in young and active patients. While many involve osteochondral lesions, isolated chondral defects also occur. Traditional treatment focuses on fixation when viable subchondral bone is present; however, managing chondral-only lesions remains controversial due to limited intrinsic healing capacity.MethodsA systematic review was conducted, screening over 300 studies since August 2023. Inclusion criteria required (1) English-language studies, (2) reports on isolated chondral fragment fixation, and (3) a minimum of 6 months of follow-up. Eighteen studies met these criteria. Data on patient demographics, lesion characteristics, fixation methods, clinical outcomes, and functional scores were extracted.ResultsA total of 76 patients (mean age: 14.3 ± 3.7 years) were analyzed. Males comprised 80.3% of the cohort. The mean follow-up was 40.3 months (range: 7-171), and the mean chondral fragment size was 4.28 cm2. The most common lesion locations were the lateral femoral condyle (34.2%), trochlea (32.2%), patella (25%), and medial femoral condyle (8.6%). Healing occurred in 96% of cases, and 86% of patients returned to sports at an average of 10.3 ± 6.1 months. Younger patients (≤14 years) had a significantly higher RTS rate (OR: 5.8; P = 0.0427). Functional scores (IKDC, KOOS, Marx, Tegner) demonstrated excellent postoperative outcomes.ConclusionDespite prior concerns regarding chondral-only fixation, this study demonstrates high healing rates and favorable functional outcomes. Direct fixation is a viable strategy, particularly in adolescents and young adults. Further prospective trials are needed to validate these findings.

Keywords: articular cartilage; chondroblasts; clinical research; clinical research chondrocytes or chondrogeneic stem cells implantation; clinical research knee; general; patellofemoral studies.

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Conflict of interest statement

The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: T.J. Kremen serves on the Boards or Committees of the AAOS and the American Orthopaedic Society for Sports Medicine and is a member of the Editorial or Governing Board of the American Journal of Sports Medicine. P.D. Fabricant is a paid consultant for BICMD, Inc.; serves on the editorial or governing board for Clinical Orthopaedics and Related Research; holds stock or stock options in HS2, LLC, HSS ASC Development Network, LLC, Joint Effort Administrative Services Organization, LLC, and Osso VR; and receives publishing royalties, financial, or material support from Springer. K. Jones is a paid consultant for Arthrex, Inc., JRF Ortho, and Vericel Corporation; receives research support from Aesculap/B. Braun, the Musculoskeletal Transplant Foundation, and Organogenesis; serves as a board or committee member for the American Orthopaedic Society for Sports Medicine, The Journal of Bone and Joint Surgery (Am), and the NFL Musculoskeletal Injury Committee; and holds stock or stock options in Sparta Biopharma.

Figures

Figure 1.
Figure 1.
PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow chart displaying the utilization of inclusion and exclusion criteria.

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