The authors reply

Derek C Angus¹, Sachin P Yende^{1

2}, Faraaz Ali Shah^{3

4}, Donald M Yealy⁵; Protocolized Resuscitation in Sepsis Meta-Analysis (PRISM) Investigators

Collaborators, Affiliations

Collaborators

Protocolized Resuscitation in Sepsis Meta-Analysis (PRISM) Investigators:
Victor B Talisa¹, Rinaldo Bellomo⁶, Chung-Chou H Chang⁷, Gregory F Cooper⁸, David Harrison⁹, Alisa Higgins¹⁰, Jason N Kennedy¹, Florian Mayr¹, Paul Mouncey¹¹, Sandra Peake¹⁰, Kathy Rowan⁹, Lu Tang¹², Sofia Triantafyllou¹³, Christopher W Seymour¹

Affiliations

¹ Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
² Integrated Veteran Care, Washington, DC.
³ Division of Pulmonary Medicine, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA.
⁴ Division of Pulmonary, Allergy, Sleep, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
⁵ Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA.
⁶ Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia; Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia; Data Analytics Research and Evaluation, Austin Hospital, Melbourne, VIC, Australia.
⁷ Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA.
⁸ Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA.
⁹ Intensive Care National Audit & Research Centre, London, United Kingdom.
¹⁰ Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.
¹¹ Department of Mathematics and Applied Mathematics, University of Crete, Crete, Greece.
¹² Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA.
¹³ Department of Mathematics and Applied Mathematics, University of Crete, Greece.

PMID: 40590651
PMCID: PMC12380193 (available on 2026-07-01)
DOI: 10.1097/CCM.0000000000006694

The authors reply

Derek C Angus et al. Crit Care Med. 2025.

. 2025 Jul 1;53(7):e1524-e1525.

doi: 10.1097/CCM.0000000000006694. Epub 2025 Jul 1.

Authors

Derek C Angus¹, Sachin P Yende^{1

2}, Faraaz Ali Shah^{3

4}, Donald M Yealy⁵; Protocolized Resuscitation in Sepsis Meta-Analysis (PRISM) Investigators

Collaborators

Protocolized Resuscitation in Sepsis Meta-Analysis (PRISM) Investigators:
Victor B Talisa¹, Rinaldo Bellomo⁶, Chung-Chou H Chang⁷, Gregory F Cooper⁸, David Harrison⁹, Alisa Higgins¹⁰, Jason N Kennedy¹, Florian Mayr¹, Paul Mouncey¹¹, Sandra Peake¹⁰, Kathy Rowan⁹, Lu Tang¹², Sofia Triantafyllou¹³, Christopher W Seymour¹

Affiliations

¹ Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
² Integrated Veteran Care, Washington, DC.
³ Division of Pulmonary Medicine, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA.
⁴ Division of Pulmonary, Allergy, Sleep, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
⁵ Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA.
⁶ Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia; Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia; Data Analytics Research and Evaluation, Austin Hospital, Melbourne, VIC, Australia.
⁷ Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA.
⁸ Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA.
⁹ Intensive Care National Audit & Research Centre, London, United Kingdom.
¹⁰ Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.
¹¹ Department of Mathematics and Applied Mathematics, University of Crete, Crete, Greece.
¹² Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA.
¹³ Department of Mathematics and Applied Mathematics, University of Crete, Greece.

PMID: 40590651
PMCID: PMC12380193 (available on 2026-07-01)
DOI: 10.1097/CCM.0000000000006694

No abstract available

PubMed Disclaimer

Conflict of interest statement

Drs. Angus, Yende, and Shah received support for article research from the National Institutes of Health (NIH). Dr. Shah’s institution received funding from the NIH. Dr. Yealy has disclosed that he does not have any potential conflicts of interest.

References

1. Coz-Yataco AO, Simpson SQ: EGDT’s Untimely Demise. Crit Care Med 2025; In Press - PubMed
1. Investigators A, Group ACT, Peake SL, et al. : Goal-directed resuscitation for patients with early septic shock. N Engl J Med 2014; 371(16):1496–1506 - PubMed
1. Pro CI, Yealy DM, Kellum JA, et al. : A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014; 370(18):1683–1693 - PMC - PubMed
1. Rivers E, Nguyen B, Havstad S, et al. : Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345(19):1368–1377 - PubMed
1. Prescott HC, Seelye S, Wang XQ, et al. : Temporal Trends in Antimicrobial Prescribing During Hospitalization for Potential Infection and Sepsis. JAMA Intern Med 2022; 182(8):805–813 - PMC - PubMed

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Authors

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Conflict of interest statement

References

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