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Editorial
. 2025 Jul;211(7):1109-1110.
doi: 10.1164/rccm.202504-0927ED.

She Loves Me, She Loves Me Not: Do Biologics Decrease Glucocorticoid Morbidity in Adults with Severe T-Helper Cell Type 2 Asthma?

Benjamin Gaston  1 , Andrew Bush  2   3   4
Affiliations
Editorial

She Loves Me, She Loves Me Not: Do Biologics Decrease Glucocorticoid Morbidity in Adults with Severe T-Helper Cell Type 2 Asthma?

Benjamin Gaston et al. Am J Respir Crit Care Med. 2025 Jul.
No abstract available

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Comment on

  • Prevention of Cardiovascular and Other Systemic Adverse Outcomes in Patients with Asthma Treated with Biologics.
    Sadatsafavi M, Tran TN, Scelo G, Tsai MJ, Busby J, Emmanuel B, Heaney LG, Jenkins C, Hoyte F, Canonica GW, Katial R, Heffler E, Wang E, Puggioni F, Wechsler ME, Ardusso LRF, Máspero J, Sivori M, Emmas C, Menzies-Gow AN, Stjepanovic N, Bosnic-Anticevich SZ, Cochrane B, Denton E, Gibson PG, Hew M, Middleton PG, Peters MJ, Brusselle GG, Louis R, Schleich F, Christoff GC, Popov TA, Bergeron C, Bhutani M, Chapman KR, Côté A, Couillard S, Dorscheid DR, Jiménez-Maldonado L, Solarte I, Torres-Duque CA, Hansen S, Porsbjerg CM, Ulrik CS, Altraja A, Bourdin A, Exarchos KP, Gogali A, Kostikas K, Makris MP, Papaioannou AI, Mitchell PD, Iwanaga T, Nagano T, Tohda Y, Al-Ahmad MS, Larenas-Linnemann D, Aarli BB, Kuna P, Chaves Loureiro C, Al-Lehebi R, Bulkhi AA, Chen W, Juang YR, Koh MS, Liu A, Rhee CK, Cosio BG, Perez-de-Llano L, Perng DW, Sheu CC, Wang HC, Mahboub B, Salameh L, Jackson DJ, Patel PH, Pfeffer PE, Lugogo N, Pleasants RA, Beastall A, Bulathsinhala L, Carter V, Eleangovan N, Fletton K, Townend J, Murray RB, Price DB. Sadatsafavi M, et al. Am J Respir Crit Care Med. 2025 Jul;211(7):1165-1174. doi: 10.1164/rccm.202501-0246OC. Am J Respir Crit Care Med. 2025. PMID: 40383109

References

    1. Sadatsafavi M, Tran TN, Scelo G, Tsai MJ, Busby J, Emmanuel B. et al. Prevention of cardiovascular and other systemic adverse outcomes in patients with asthma treated with biologics. Am J Respir Crit Care Med . 2025;211:1165–1174. - PubMed
    1. Nair P, Wenzel S, Rabe KF, Bourdin A, Lugogo NL, Kuna P. et al. ZONDA Trial Investigators. Oral glucocorticoid-sparing effect of benralizumab in severe asthma. N Engl J Med . 2017;376:2448–2458. - PubMed
    1. Menzies-Gow A, Corren J, Bourdin A, Chupp G, Israel E, Wechsler ME. et al. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med . 2021;384:1800–1809. - PubMed
    1. Bhatt SP, Rabe KF, Hanania NA, Vogelmeier CF, Bafadhel M, Christenson SA. et al. Dupilumab for chronic obstructive pulmonary disease with type 2 inflammation: a pooled analysis of two phase 3, randomised, double-blind, placebo-controlled trials. Lancet Respir Med . 2025;13:234–243. - PubMed
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