The effect of diflunisal administration on platelet aggregation and cerebral blood flow
- PMID: 4059301
Item in Clipboard
The effect of diflunisal administration on platelet aggregation and cerebral blood flow
Pharmatherapeutica.
1985.
Abstract
The effect of a high dose of diflunisal (750 mg twice daily) on platelet aggregation and cerebral blood flow was investigated in 8 healthy volunteers. Diflunisal inhibited platelet aggregation consistently; this effect on platelets was reversed within 24 hours after the last dose of diflunisal. There was, however, no correlation between the anti-aggregatory effect of diflunisal and its plasma concentration. Diflunisal did not alter cerebral blood flow.
Similar articles
-
Actions and interactions of acetylsalicylic acid, salicylic acid and diflunisal on platelet aggregation.Eur J Clin Pharmacol. 1984;27(2):165-8. doi: 10.1007/BF00544040. Eur J Clin Pharmacol. 1984. PMID: 6499897
-
Effects of diflunisal on platelet function and fecal blood loss.Pharmacotherapy. 1983 Mar-Apr;3(2 Pt 2):65S-69S. Pharmacotherapy. 1983. PMID: 6344041 Clinical Trial.
-
[Is the effect of naloxone on cerebral circulation mediated by blood platelets?].Cesk Neurol Neurochir. 1989 Jul;52(4):277-81. Cesk Neurol Neurochir. 1989. PMID: 2791071 Slovak.
-
[Action of some salicylates associated with other non-steroidal anti-inflammatory drugs on the release of prostacyclin from the gastric mucosa of the rat].Boll Soc Ital Biol Sper. 1982 Dec 30;58(24):1666-71. Boll Soc Ital Biol Sper. 1982. PMID: 6762887 Italian.
-
Review of the animal and clinical pharmacology of diflunisal.Pharmacotherapy. 1983 Mar-Apr;3(2 Pt 2):9S-22S. Pharmacotherapy. 1983. PMID: 6344042 Review.
Cited by
-
The effect of tiaprofenic acid and indomethacin on in vitro prostaglandin synthesis by rat, rabbit and human stomach tissue.Agents Actions. 1985 Dec;17(2):205-8. doi: 10.1007/BF01966593. Agents Actions. 1985. PMID: 4096305